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57th Annual ESPE

Athens, Greece
27 Sep 2018 - 29 Sep 2018

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ESPE 2018 57th European Society for Paediatric Endocrinology Annual Meeting 27-29 September 2018 Athens, Greece

Rapid Free Communications

Diabetes and Insulin 2

hrp0089rfc12.1 | Diabetes and Insulin 2 | ESPE2018

Use of Acid-Suppressivemedications During Infancy and Early Childhood and Its Association with Type 1 Diabetes

Menon Sruthi , Umapathi Krishna Kishore , Thavaman Aravind , Bora Geetanjali , Davis Ajuah

Background: Type 1 diabetes is a multifactorial, immune mediated disease whose incidence has been increasing worldwide. These changes in prevalence cannot be explained by genetic susceptibility alone and several lifestyle changes have been linked to the rising incidence including obesity, diet and mode of delivery. Many of these environmental factors influence the composition of the gut microbiome which interacts with the immune system as well as affects gut permeability, thus...

hrp0089rfc12.2 | Diabetes and Insulin 2 | ESPE2018

Bone Mineral Density is Increased in 276 Danish Children and Adolescents with Type-1-Diabetes

Madsen Jens Otto Broby , Herskin Camilla Winther , Zerahn Bo , Olsen Birthe Susanne , Pociot Flemming , Johannesen Jesper

Objectives: Bone health is affected in Type-1-Diabetis (T1D) causing higher risk of hip fractures, prolonged fracture healing and altered bone mineral density (BMD). In T1D adults BMD is found to be decreased. In this study we have measured the BMD in children and adolescents from the Copenhagen Pediatric T1D Cohort.Methods: 276 children and adolescents (131 girls) were included from the diabetes outpatient clinic at Herlev University Hospital. All patie...

hrp0089rfc12.3 | Diabetes and Insulin 2 | ESPE2018

Barriers and Sources of Support for the Performance of Physical Activity in Pediatric Type 1 Diabetes

Livny Ruth , Said Wasim , Shilo Smadar , Gal Shoshana , Oren Meirav , Weiss Ram , Zuckerman-Levin Nehama , Shehadeh Naim , Cohen Michal

Background: The advantages of physical activity are particularly emphasized in children with type-1-diabetes and 60 minutes of regular daily activity is recommended. However, reports suggest that children with type-1-diabetes perform less than the recommended daily activity and are less active than their non-diabetic peers. This study aimed to: i) Identify barriers and sources of support for exercise performance in children and adolescents with type-1-diabetes. ii) Identify st...

hrp0089rfc12.4 | Diabetes and Insulin 2 | ESPE2018

Use of Telemonitoring Via a Mobile Device App Reduces HbA1c in Type 1 Diabetic Children and Adolescents

Klee Philippe , Bussien Catherine , Castellsague Montserrat , Combescure Christophe , Dirlewanger Mirjam , Girardin Celine , Mando Jean-Luc , Perrenoud Luz , Salomon Carole , Schneider Franck , Schwitzgebel Valerie

Background and Aims: Type 1 diabetes mellitus (T1DM) belongs to the most common chronic diseases affecting children and adolescents. Technological advances have improved metabolic control over the past decades, thereby decreasing the risk of long-term complications. However, only a minority of patients meets the treatment goals of maintaining a glycated hemoglobin (HbA1c) level below 7.5% (58 mmol/mol). Webdia is an application for mobile devices developed by the fath...

hrp0089rfc12.5 | Diabetes and Insulin 2 | ESPE2018

Insulin Gene Promoter Methylation Status in Greek Children and Adolescents with Type 1 Diabetes

Mouzaki Konstantina , Kotanidou Eleni P , Fragou Aikaterini , Giza Styliani , Kleisarchaki Angeliki N , Tsinopoulou Vasiliki Rengina , Serbis Anastasios , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: Insulin (INS) gene is reported to be the most important gene involved in Type 1 Diabetes (T1D); its expression is inversely correlated with methylation at CpG sites. Hypermethylated primers are associated with decreased expression.Aim: The present study aims to investigate possible differences in DNA methylation pattern between T1D youngsters and healthy controls.Patients and Methods: Twenty T1D parti...

hrp0089rfc12.6 | Diabetes and Insulin 2 | ESPE2018

AMGLIDIA, a Suspension of Glibenclamide for Patients with Neonatal Diabetes, Long Term Data on Efficiency and Tolerance

Beltrand Jacques , Meyzer Candice , Colas Sandra , Semeraro Michaela , Godot Cecile , Treluyer Jean-Marc , Elie Caroline , Polak Michel

Background: Glibenclamide has proven to be efficient for patients with neonatal diabetes owing to potassium channel mutations. We developed a suspension of glibenclamide (EMA CHMP Authorization February 2018) fitting recommendations of drug administration to allow a precise dosage. We reported it to be practical, efficient and well tolerated after 3 months of use.Objective: To determine long term efficiency and tolerance of a new suspension of glibenclam...