ESPE Abstracts (2018) 89 P-P3-072

Severe Hypertriglyceridemia and Multiple Autoimmune Phenomenon at new onset Type 1 DM

Aashish Sethi, Smita Ramachandran & Inderpal Kochar

Indraprastha Apollo Hospital, Delhi, India

Introduction: Type 1 Diabetes is a condition associated with deficiency of insulin, which is a key regulator of carbohydrate and fat metabolism. Most newly diagnosed type 1 diabetes present with diabetic ketoacidosis, which is a triad of hyperglycemia, ketonemia and acidosis. It usually presents with features of acidosis such as lethargy, dehydration, and tachypnea.

Case: We present a case that presented to us with a lipemic blood sample and on further workup was diagnosed with diabetic ketoacidosis with hypertriglyceridemia with multiple autoimmune phenomenon positivity. She was closely monitored and treated as per protocol for DKA, no lipid lowering agents were give and her lipids came back by to normal levels by 96 hours of diagnosis.

Conclusion: Only 11 cases have been reported describing pediatric patients (age<18 years) with DKA and severe hypertriglyceridemia (Triglyceride>1000), on the contrary several large case series and cases have been reported in adults describing the same. Pediatricians should be aware about complications associated with severe hypertriglyceridemia such as acute pancreatitis and cerebral edema.

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