ESPE Abstracts (2018) 89 P-P3-086

Continuous Subcutaneous Insulin Infusion in Children and Adolescents: Analysis of Initial and Follow Up Basal Rates

Gunay Demir, Sukran Darcan, Samim Özen, Hafize Işıklar, Yasemin Atik Altınok & Damla Goksen

Ege University Faculty of Medicine Departement of Ped Endocrinology and Diabetes, İzmir, Turkey

Objective: Initiation of continuous subcutaneous insulin therapy (CSII) requires an appropriate basal rate profile. Although different approaches exist; there is a lack of evidence-based recommendations, especially in young children. Our aim was to show how the % of basal rates change at the end of first year of therapy when basal rates are equally distributed at the start of therapy.

Materials and Methods: In this survey, 129 CSII patients were analyzed. Patients were divided into four age groups: <5 yr (n=27), 5 to < 8 yr (n=20), 8 to <12 yr (n=33), 12 to <15 yr (n=28), 15 to < 18 yr (n=16) and > 18 yr (n=5). Basal insulin requirement and diurnal distribution were evaluated at the initiation of pump therapy and in the first year.

Results: Basal insulin requirement did not differ between the beginning of therapy and first year (Table 1). In every age group basal insulin (U/kg) circadian insulin profiles were different except in the group 12 to <15 yr. As a result, at the start of pump therapy basal rates should be designed according to circadian rhythm.

Table 1 Basal rates according to age groups at the beginning and first year.
Basal İnsulin beginning U/kg1 st Year Basal insulin U/kg p
0–5 yr n:270.41±0.880.26±0.680.13
5–8 yr n:200.29±0.120.30±0.090.50
8–12 yr n:330.31±0.130.32±0.090.27
12–15 yr n:280.33±0.080.35±0.090.34
15–18 yr n:160.32±0.100.34±0.110.43
>18 yr n:50.22±0.050.24±0.060.5
p: basal and first year change pa: change according to age groups.

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