ESPE Abstracts (2018) 89 P-P3-223

Coeliac Disease in Turner Syndrome More Frequent Than Expected

Baz Ouidada, Semrouni Mouradb, Sakher Samiaa & Mimouni Zerguini Safiaa

aPierre and Marie Curie Center, Algiers, Algeria; bBeni messous Hospital, Algiers, Algeria

Abstract: The risk of developing coeliac disease (CD) is higher in Turner syndrome (TS) than the general population, and screening has been recommended in asymptomatic individuals known to have an increased risk of developing the disease. In light of this recommendation, the aim of the study was to assess prevalence of celiac disease in Turner syndrome.

Patients and methods: Serological screening of coeliac disease were performed in 85 children and adolescent with Turner syndrome during the last 3 years (since 2015). Serological investigations were repeated yearly, and the results of screening of new patients were completed.

Results: Positive serologic results were found in nineteen 19 of 85 patients (22%). Intestinal biopsy was applied in all cases. Coeliac disease was revealed by histologic analysis in 12 cases - 12/85 (14%).

Conclusion: The prevalence of celiac disease in Turner syndrome patients observed in the present study is quite high and seems to indicate that the connection between these disorders can not be coincidental. Their cases and the available data from the publications indicate that screening of coeliac disease in patients with Turner syndrome should be performed and intestinal biopsy is recommended in positive cases.

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