ESPE2019 Poster Category 3 Late Breaking Abstracts (69 abstracts)
Circulating Chemerin may be Associated with Early Vascular Pathology in Obese Children without Overt Arterial Hypertension – Preliminary Results
Małgorzata Wójcik 1 , Agnieszka Kozioł-Kozakowska 2 , Dominika Januś 1 , Aleksandra Furtak 1 , Agnieszka Małek 3 , Krystyna Sztefko 3 & Jerzy Starzyk 1
1Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University, Medical College, Kraków, Poland. 2Department of Pediatrics, Gastroenterology and Nutrition, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland. 3Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University, Medical College, Kraków, Poland
Elevated chemerin level is observed in obese patients with metabolic syndrome and arterial hypertension but it is not known if measurement of this hormone have any prognostic value before the occurrence of clinically overt complications of obesity. The aim of the study was to investigate the relationship between serum chemerin level and 24h blood pressure monitoring (ABPM), and intima media thickness in obese children.
Methods: The study included 23 children (13 girls, mean age 9.3, SD 1.9) with obesity (mean BMI SDS 3.9, SD 1.7) without overt arterial hypertension, and metabolic complications of obesity. ABPM, ultrasound of carotid arteries and aorta, and plasma chemerin concentrations quantified by ELISA, were performed in each participant.
Results: There was no significant correlation of circulating chemerin with anthropometric measurements (BMI SDS, weight to height excess, waist circumference, fat percent in the whole body). There was a significant correlation of circulating chemerin level with systolic blood pressure load in ABPM (r=0.5, P<0.05). There was no significant correlation of circulating chemerin with ultrasound markers of atherosclerosis (carotid intima media thickness r=0.4, aorta intima media thickness r=0.3).
Conclusion: Increased concentration of chemerin is an important risk factor for increased systolic blood pressure in children with obesity, even before clinically overt hypertension develops.
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