Diabetes and Insulin

hrp0092p2-62 | Diabetes and Insulin | ESPE2019

The Effect of Carbohydrate Recognition and Counting Ability on Glycemic Control in Pediatric Patients with Type 1 Diabetes

Minutti Carla , Mullen Mary , Bindiganavle Aparna , Parish Anthony

Many factors contribute to the glycemic control in pediatric patients with type 1 diabetes mellitus (T1DM). The purpose of this IRB approved study was to determine if there was a significant correlation between the ability of pediatric patients with TiDM to accurately recognize and count carbohydrates and their hemoglobin A1C (HgbA1C). T1DM patients aged 12-17 years completed the Koontz PedCarbQuiz (PCQ) . Demographic and clinical data was extracted from the electronic health ...

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hrp0092p2-63 | Diabetes and Insulin | ESPE2019

A Rare Case of Syndromic Diabetes due to an INSR Pathogenic Variant

Tayeb Tara , Amaratunga Shenali , Kucerová Petra , Pruhová Štepanka , Lebl Jan

Introduction: The main type of diabetes seen in pediatric clinical practice is type 1 diabetes. Monogenic diabetes and syndromic diabetes are rare, but can be more common in areas where consanguinity is high.A 12-year-old girl born to consanguineous parents who are first cousins, was referred after being diagnosed with diabetes and severe diabetic ketoacidosis. In addition, she had hypertrichosis, coarse facial features, acanthosis nigri...

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hrp0092p2-64 | Diabetes and Insulin | ESPE2019

Autoimmune Thyroid Diseases in Children and Adolescents with Maturity Onset Diabetes of the Young

Calcaterra Valeria , Regalbuto Corrado , Dobbiani Giulia , Vinci Federica , Montalbano Chiara , Larizza Daniela

Background and Aim: The relationship between T1DM and autoimmune thyreopathies is known and described, but the relationship between thyreopathies and other type of diabetes is not sufficiently clarified in pediatric age. The aim of our study was to assess the prevalence of autoimmune thyroid diseases (ATD) in children and adolescents with maturity onset diabetes of the young (MODY) in comparison with patients with T1DM and control group....

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hrp0092p2-65 | Diabetes and Insulin | ESPE2019

Abstract Unavailable....

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hrp0092p2-66 | Diabetes and Insulin | ESPE2019

New Mutation of the PDX-1 Gene Causes MODY Type 4 Diabetes in a 17 year old girl with Good Response to Oral Antidiabetics

Giatropoulou Sofia , Kamrath Clemens , Krull Simone , Wudy Stefan

Background: Correct classification of diabetes mellitus in children and adolescents is essential for appropriate treatment.Case report: A 17 year old female adolescent was referred to our clinic due to hyperglycemia. She complained of dizziness and nausea. Her blood pressure was 160 /100 mmHg; she had hyperglycemia ( 208 mg/dl), a glycosuria and a ketonuria without ketoacidosis. Some members of the family were on insulin...

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hrp0092p2-67 | Diabetes and Insulin | ESPE2019

Periodontal Disease Among Children and Adolescents with Type 1 Diabetes Mellitus

Babiker Omer , Osuji Oliver , Qudah Mansour , Al Brahim Nahla

Periodontal disease is defined as inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. It results from an extension of inflammation from the gingiva into deeper periodontal tissue. Periodontal disease is well studied among the adult population. Diabetes mellitus is considered as one of its risk factors among adults. We conducted this cross-sectional pilot study to investigate the association of periodontal disease and metabolic c...

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hrp0092p2-68 | Diabetes and Insulin | ESPE2019

Pancreatic β Cell Function and its Relationship with Iron Overload in Patients with β-Thalassemia Major

Zhang Lina , Liang Liyang , Jiang Zhuannan , Meng Zhe , Ou Hui , Liu Zulin , Hou Lele , Haung Siqi

Objective: The functional status and influencing factors of pancreatic beta cells in patients with β-thalassemia major (β-TM) were investigated.Methods: A cross-sectional study was conducted in 88 patients with β-TM, with an average age of 11.3±5.6 years. Thirty-two healthy subjects were selected as the control group. FBG, FINS, HOMA-IRI, HMOA-ISIand HOMA-β FI were calculated between ...

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hrp0092p2-69 | Diabetes and Insulin | ESPE2019

Gluten-free Diet in Children with Recent Onset Type 1 Diabetes is Associated with Slower Pace of C-peptide Decline, Better Metabolic Control and Lower Insulin Requirement at 12 months

Neuman Vít , Pruhová Štepánka , Kulich Michal , Funda David P. , Koloušková Stanislava , Vosáhlo Jan , Romanová Martina , Petruželková Lenka , Obermannová Barbora , Cinek Ondrej , Šumník Zdenek

Objectives: Data on the role of gluten in type 1 diabetes (T1D) pathogenesis are scarce. We aimed to test whether gluten-free diet (GFD) can decelerate the decline in beta-cell capacity in newly diagnosed non-coeliac T1D children.Methods: Forty six children (aged 10.2±3.3 years) were recruited into this non-randomized self-selected intervention trial: 26 started with GFD, whereas 20 remained on standard diet. Main o...

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hrp0092p2-70 | Diabetes and Insulin | ESPE2019

Evaluation of β-cell Function in Young MODY Patients using a Mixed Meal Tolerance Test

Stankute Ingrida , Morkunaite Ausra , Dobrovolskiene Rimante , Danyte Evalda , Razanskaite-Virbickiene Dovile , Jasinskiene Edita , Mockeviciene Giedre , Schwitzgebel Valerie , Verkauskiene Rasa

Background: Mixed meal tolerance test (MMTT) is a gold standard for evaluating β-cell function. There is limited data on MMTT and β-cell function in MODY patients.Objective: The aim was to analyze plasma C-peptide (CP) levels during MMTT in MODY patients as a biomarker of β-cell function.Methods: The cohort consisted of 39 patients with MODY genes mutations:...

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hrp0092p2-71 | Diabetes and Insulin | ESPE2019

The Effect of Different Forms of Maternal Dysglycemia on the occurrence of Neonatal Hypoglycemia in babies admitted to NICU.

TAWFIK SOLIMAN ASHRAF , Salama Husam , Al Rifai Hilal , Al-Obaidly Sawsan , Al Qubasi Mai , Olukade Tawa

Abstract: We report the effect of different forms of dysglycemia on the occurrence of neonatal hypoglycemia in a large cohort of pregnant women studied as a part of a PEARL-Peristat Study, funded by QNRF- Doha-QatarMethods: Out of 12255 pregnant women screened during 2016-2017, 3027 women were identified with gestational diabetes (GDM) (WHO criteria) and 233 were diabetic (DM) before pregnancy. All dysglycemic women were...

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hrp0092p2-72 | Diabetes and Insulin | ESPE2019

Adropin, Afamin And Neudesin - Novel Biomarkers of Type 1 Diabetes Mellitus in Children

Noiszewska Klaudyna , Bossowski Artur

Introduction: The incidence of type 1 diabetes mellitus (DM I) is rising. Newly discovered peptides: adropin, afamin and neudesin may play a key role in the diagnostic process in the future. Most studies assessing the relationship of those peptides provide data obtained from studies conducted on animals, adults with type DM II and women with gestational DM. There are only few studies concerning these relationships in children.Aim of the ...

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hrp0092p2-73 | Diabetes and Insulin | ESPE2019

Prevalence, Time Trend and Predictors of Celiac Disease in Type 1 Diabetes

Agarwal Neha , Dave Chetan , Patel Riddhi , Shukla Rishi , Bajpai Anurag

Background: Celiac disease is an important association of type 1 diabetes with significant impact on growth and glycemic control. Identification of the disease in asymptomatic subjects highlights the need for celiac screening in type 1 diabetes. Disparity in screening guidelines suggests the need for exploration of time trend and predictors of the association.Objective: To estimate the time trend, prevalence and predicto...

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hrp0092p2-74 | Diabetes and Insulin | ESPE2019

Impact of the Flash Glucose Monitoring System on Children with Type 1 Diabetes After the First Year of Using in Systematic Way

Freijo Martin Concepcion , Bertholt Zuber Laura , Palenzuela Inmaculada

The Flash glucose monitoring System(FGMS) is a system of measurement of the interstitial glucose levels in real time, safe, effective and doesn´t require calibration. Its low cost has allowed to be approved for all children under 18 years old by our Regional Health Service.Objective: To assess the impact during this first year of use of FGMS in all children diagnosed with type 1 diabetes who previously used the classic method of cap...

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hrp0092p2-75 | Diabetes and Insulin | ESPE2019

Insulin Treatment of Cystic Fibrosis Related Diabetes (CFRD) on BMI and Respiratory Function

Giugno Andrea , Lo Presti Donatella , Leonardi Salvatore , Parisi Giuseppe , Timpanaro Tiziana , Papale Mariella , Rotolo Novella , Sauna Alessandra , Caruso-Nicoletti Manuela

Cystic fibrosis related diabetes (CFRD) is one of the main complications of cystic fibrosis (CF), following inflammatory-degenerative damage of the pancreas. Aim of our study was to evaluate the effects of replacement insulin therapy in patients with cystic fibrosis complicated by overt diabetes or pre-diabetes on BMI and respiratory function. We selected a sample of 17 insulin treated patients (Group T) and a sample of 17 controls with CF but normal glucose metabolism (Group ...

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hrp0092p2-76 | Diabetes and Insulin | ESPE2019

Coexistence of Medium chain acyl-CoA dehydrogenase deficiency (MCADD) and Type 1 diabetes (T1D): A management challenge

Afreh-Mensah Donald , Agwu Juliana C.

Background: Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive fatty acid β-oxidation defect. The enzyme is important in the breakdown of medium chain fats into acetyl-CoA to produce ketones, alternative energy source when glucose hepatic glycogen stores become depleted during prolonged fasting. In MCADD, during periods of fasting/ acute illness, there are insufficient ketones to compensate for the glucose energy deficit, ...

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hrp0092p2-77 | Diabetes and Insulin | ESPE2019

Education in type 1 Diabetes Mellitus (T1D): what do Educators Really Know? A Tunisian Multicenter Study among Young Doctors, Nurses and Nutritionnists

ESSADDAM Leïla , KALLALI Wafa , MELLITI Safa , KHALSI Fatma , FDHILA Faten , BEN CHEHIDA Amel , KHLAIFIA Zied , BOUSSETTA Khedija , KHEMIRI Monia , TEBIB Neji , MAHERZI Ahmed , FITOURI Zohra , BEN BECHER Saayda

Background: Type1 diabetes mellitus is increasing worldwide in childhood. Education is an essential part of the package care at diagnosis. It adresses children with newly diagnosed type 1 diabetes and their families and is made by young doctors and paramedical staff (nurses and nutritionnists).Objective: to assess the knowledge of the medical and paramedical staff concerning the global management of type 1 diabetes in ch...

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hrp0092p2-78 | Diabetes and Insulin | ESPE2019

A Case of an Infant with Congenital Hyperinsulinism Complicated by Diabetic Ketoacidosis during Treatment

Yoo Chaeri , Rhie Seonkyeong , Yoo Eun-Gyong , Jung Mo Kyung

Background: Congenital hyperinsulinism (CHI) is a disorder causing persistent hypoglycemia due to oversecretion of insulin. Diazoxide, a KATP channel opener in pancreatic beta cells is the treatment of choice, however, the glucose level should be monitored carefully. We report here a case of an infant girl with CHI who was complicated by diabetic ketoacidosis (DKA) during acute febrile illness.Case Report: A 1...

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hrp0092p2-79 | Diabetes and Insulin | ESPE2019

Clinical Profile and Follow-up Analysis of Neonatal Diabetes Mellitus- Single Centre Experience

Korula Sophy , George Paul Praveen , Chapla Aaron , Mathai Sarah , Simon Anna

Aim: To study the clinical profile of Neonatal Diabetes Mellitus (NDM) at our centreObjectives: 1. To study follow-up data on growth, glycemic control2. To review genetic analysisIntroduction: NDM is rare and occurs at a frequency of 1:1,00,000. There is scarce literature on follow up of these patients although genetic data is well established (1). Developing...

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hrp0092p2-80 | Diabetes and Insulin | ESPE2019

Effect of Multiple dose Insulin on Glycaemic Control and Adiposity in Children and Adolescents with Type 1 Diabetes; a Sri Lankan Experience

Hashim Raihana , Hoole Thabitha , Prematilake Dilusha , Kollurage Udeni , Gunasekara Buddi , Suntharesan Janani , Atapattu Navoda

Objective: To describe the glycaemic control and change in body mass index (BMI) in children and adolescents with type 1 diabetes (T1DM) after converting to multiple dose insulin regime (MDI) from fixed dose insulin regime (FD).Methods: A retrospective observational study on children with T1DM who were converted to MDI from FD at the Lady Ridgeway Hospital from January 2013 to June 2018. Mean haemoglobin A1c(H...

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hrp0092p2-81 | Diabetes and Insulin | ESPE2019

A de novo Pathogenic Heterozygous Mutation of the Insulin Receptor gene in a Patient with type A Insulin Resistance Syndrome

Sun Manqing , Wang Wei , Lu Wenli , Zhang Lidan , Dong Zhiya , Xiao Yuan , Ma Xiaoyu , Ni Jihong , Wang Defen

Background: Defects of the insulin receptor gene (INSR) can cause genetic syndromes associated with a wide diverse range of congenital insulin resistance from milder insulin-resistant diabetes mellitus (Type A insulin resistance syndrome, TAIRS) to leprechaunism (Donahue syndrome). Clinical features in TAIRS vary due to the severity of damage in INSR, precise diagnosis is challenging.Materials and Methods</stron...

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hrp0092p2-82 | Diabetes and Insulin | ESPE2019

Thiamine Responsive Megaloblastic Anemia Syndrome with Restrictive Cardiomyopathy: A case report

Laimon Wafaa

Background: Thiamine-responsive megaloblastic anemia syndrome (TRMA), also known as Rogers syndrome, is characterized by megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Disturbances of the thiamine transport into the cells results from homozygous mutation in the SLC19A2 gene. Rhythm disturbances and structural cardiac anomalies have been described in the syndrome.Case presentation: We report a bo...

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hrp0092p2-83 | Diabetes and Insulin | ESPE2019

17q12 Deletion and a Family History of Diabetes

Kasongo Laura , Nicolescu Ramona

Introduction: 17q12 deletion syndrome is associated with an enlarging phenotype, the most frequent clinical findings being renal and genitourinary malformations, diabetes mellitus (β-cell developmental defect) and exocrine pancreas deficiency, variable cognitive impairment with dysmorphic features.Diabetes, known as MODY 5 (maturity-onset diabetes of the young), is an autosomal dominant monogenic type and the most commonly identi...

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hrp0092p2-84 | Diabetes and Insulin | ESPE2019

An Unusual Presentation of Type 1 Diabetes

Alwadiy Faisal , Bui Helen

Introduction: Hyperglycemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are life-threatening emergencies in diabetic patients. While DKA at presentation of T1D in children represents about 25% of cases, HHS is very unusual as a first presentation.Case: A 10 year old Haitian-Sudanese boy presented to our ER for obtundation. He had a 10 day history of polydipsia and polyuria followed later by vomiting, for...

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hrp0092p2-85 | Diabetes and Insulin | ESPE2019

Clinical Characteristics and Treatment Outcomes in Patients with Autoantibody-negative Ketosis-prone Diabetes

Kim Shin-Hee , Ahn Moon-Bae , Kim Seulki , Choi Yujung , Lee Seonhwa , Cho Won Kyoung , Cho Kyoung Soon , Jung Min Ho , Kyu Suh Byung

Objective: Ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA) in patients lacking the typical features of autoimmune type 1 diabetes, is a heterogeneous syndrome. The objective of this study is to ascertain the presence of A-β+ (autoantibody-negative, β-cell functional reserve) KPD in Korean children and adolescents and to study their characteristics in this group. Method: Diabetes ...

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hrp0092p2-86 | Diabetes and Insulin | ESPE2019

Factors Influencing the Formation and Support of the Motivation to Self-control of Adolescents with Type I Diabetes Mellitus

Kyrylova Olena

Background: Indicators of Type 1 diabetes mellitus in children and adolescents in Ukraine have increased in recent years. The effectiveness of treatment of this disease depends not only on the level of medical support of the patient, but also on the training of patients in the principles of managing their own illness. Low motivation of patients for treatment and control of illness, refusal to bear responsibility for their state of health and well-being can sig...

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hrp0092p2-87 | Diabetes and Insulin | ESPE2019

Glycemic Control in Egyptian Adolescent Girls with Type 1 DM

Shaalan Yomna , Badawi Nora , Soliman Aliaa

Background: Adolescents with Type 1 Diabetes (T1D) have worse metabolic control than preadolescent children due to poor adherence with medications and insulin resistance related to puberty hormones. Adolescent girls are at a particular risk for poor control as insulin sensitivity decreases in the luteal phase and menstrual cycle. Progesterone, secreted in the second half of the cycle, may cause an increase in appetite and caloric intake....

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hrp0092p2-88 | Diabetes and Insulin | ESPE2019

A Qualitative Study Investigating the Experiences of Using Solution Focused Therapy in a Paediatrics Diabetes Team

Guyers Mark , Ziemba Dominka , Bray Dr Dominic , May Ng Dr Sze

Introduction: It is essential that children and young people with diabetes are supported to manage their diabetes effectively to prevent the development of early complications, by education and self-management aimed towards maintaining good glycaemic control. However, the common clinical challenge is difficultly in engaging adolescents and young people with poor glycemic control in their diabetes management.Solution Focus Therapy (SFT) h...

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hrp0092p2-89 | Diabetes and Insulin | ESPE2019

The Prevalence of Chronic Kidney Disease in Children and Adolescents with Type 1 Diabetes Mellitus in The Republic of Uzbekistan

Rakhimova Gulnara , Sadikova Akidahon

Chronic kidney disease (CKD) is one of the most significant medical and socio-economic problems of our time.Purpose of the Research: To study the prevalence of chronic kidney disease in children and adolescents with type 1 diabetes in Uzbekistan.Materials and Methods: For conducting epidemiological studies there were examined children and adolescents of type 1 diabetes. Epidemiological data were st...

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hrp0092p2-90 | Diabetes and Insulin | ESPE2019

Neonatal Diabetes in Two Siblings with Foxp3 Variant

Colombi Carolina , Tornese Virginia , Pott Godoy Clara , Peña Sonia , De Franco Elisa , Guntsche Zelmira

Background: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by loss-of-function mutations in the gene encoding the forkhead box P3 (FOXP3) transcription factor. This factor plays a key role in the differentiation and function of CD4+ CD25+ regulatory T cells, essential for the establishment and maintenance of natural tolerance.Objective: To describe clinic...

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hrp0092p2-91 | Diabetes and Insulin | ESPE2019

A Novel Variant of the WFS1 Gene with Dominant Inheritance Causing Wolfram-like Syndrome

Stanik Juraj , Skopkova Martina , Varga Lukas , Masindova Ivica , Jancova Emilia , Profant Milan , Gasperikova Daniela

Aims/hypothesis: The Wolfram syndrome, also known as the DIDMOAD syndrome (Diabetes Insipidus, early-onset Diabetes Mellitus, progressive Optic Atrophy, and Deafness), is mostly associated with recessive mutations in the WFS1 gene. However, dominant mutations in the WFS1 gene were described as causing less severe Wolfram-like syndrome, or isolated optic atrophy, or low-frequency sensorineural hearing loss.Method...

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hrp0092p2-92 | Diabetes and Insulin | ESPE2019

An Impaired Lipid Profile is a Sign of Reduced Insulin Sensitivity in Children and Adolescents at Type 1 Diabetes Onset

Maltoni Giulio , Zucchini Stefano , Zioutas Maximiliano , Di Natale Valeria , Cassio Alessandra

At type 1 diabetes (T1D) onset, international guidelines reccommend a starting subcutaneous insulin dose widely ranging from 0,5 to 1 u/kg/day. In fact, many factors such as age, pubertal stage and the severity of ketoacidosis, may influence insulin sensitivity. However, it is a common experience that many subjects may require a higher insulin daily dose than expected, with the subsequent need of longer time to achieve stable blood glucose values and the extension of days of h...

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hrp0092p2-93 | Diabetes and Insulin | ESPE2019

The Growth Hormone Treatment and Carbohydrate Metabolism in Children Born Small for Gestational Age

Labochka Dominika , Witkowska-Sedek Ewelina , Milczarek Monika , Kucharska Anna

Background: Children who were born small for gestational age (SGA) or with intrauterine growth restriction (IUGR) have increased risk of metabolic disorders such as insulin resistance, diabetes mellitus type 2 and coronary disease in adultness. Most of those children after catch-up growth achieve the same growth as their peers. Nevertheless 10 % of them persist finally short as adults. In the last decade some countries introduced the rhGH treatment to impr...

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hrp0092p2-94 | Diabetes and Insulin | ESPE2019

Empirical Sulphonyurea in Neonatal Diabetes: Results from a aTertiary Care Centre

Ramachandran Smita , Kochar Inderpal

Background: To study the genetic profile of infants with neonatal diabetes (NDM) and response to empirical glibenclamide.Method: A retrospective study between 2014-2018, the data retreived from patients admitted with neonatal diabetes with genetic analysis. Started on insulin and empirical glibenclamide given in selected cases to evaluate the effects. Glibenclamide was started in 4 children who were not euglycemic on ins...

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hrp0092p2-95 | Diabetes and Insulin | ESPE2019

Diabetes Mellitus, Severe Acanthosis Nigricans and Short Stature: a Rare Association in Chinese Children

Zhang Miaoying , Pei Zhou , Xi Li , Zhao Zhuhui , Li Xiaojing , Wu Bingbing , Luo Feihong

Objectives: To report a case of concomitance of diabetes mellitus, severe acanthosis nigricans, short stature in a 6-year boy.Methods: Retrospective review of medical records of a patient with diabetes, acanthosis nigricans and short stature followed at the Departments of Endocrinology and Metabolism, Children's Hospital of Fudan University. This rare case was undergoing whole exome sequencing....

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hrp0092p2-96 | Diabetes and Insulin | ESPE2019

Evaluation of Celiac Disease Antibodies and 25-OH Vitamin D in Type 1 Diabetic Patients

Navasardyan Lusine , Ghubatyan Anna , Arzumanyan Angelina , Gevorgyan Nune , Aghajanova Elena

Background: In diabetic patients vitamin D seems to play a role not only on bone metabolism, but also on many other organs and/or systems, such as lipid profile, cardiovascular system, etc. We decided to evaluate whether the celiac disease antibodies in type 1 diabetic patients have a connection with 25-OH vitamin D status.Materials and Methods: 78 young patients with type 1 diabetes were evaluated with mean age of 14&#1...

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hrp0092p2-97 | Diabetes and Insulin | ESPE2019

Does Commencing on an Insulin Pump Improve Glycaemic Control in Paediatric Patients?

Prathivadi Bhayankaram Nuthana , Riddle Miles

Background: Long-term outcomes in diabetic patients are associated with good glycaemic control. In the UK, the National Institute of Clinical Excellence recommends that insulin pump therapy is used for patients when multiple injections are impractical or inappropriate (Guideline 151, 2008). However, insulin pumps are very expensive and some previous studies do not suggest a significant improvement in glycaemic control compared with multiple injections. The aim...

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hrp0092p2-98 | Diabetes and Insulin | ESPE2019

Prevalence of Neonatal Macrosomia (NM) and Its Relation to Hypoglycaemia (NH) in Normoglycemic Versus Dysglycemic Pregnant Women.

SOLIMAN ASHRAF , Salama Husam , Al Rifai Hilal , Al-Obaidly Sawsan , Al Qubasi Mai , Olukade Tawa

Introduction: Several factors contribute to the risk of neonatal macrosomia (NM) and its associated hypoglycemia (NH) in pregnant women.Objective: To determine the prevalence of NM and its association with NH in a large cohort of normoglycemic and dysglycemic women.Methods: Out of 12255 pregnant women screened during 2016-2017, 3027 women were identified with gestational diabetes (...

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hrp0092p2-99 | Diabetes and Insulin | ESPE2019

A Case of Neonatal Diabetes Due to Newly Defined Mutation in the GLIS 3 Gene

Kor Yilmaz , Demet Akbas Emine , De Franco Elisa

Introduction: GLIS3 is a member of the GLI-similar zinc finger protein family encoding for a nuclear protein that maps to chromosome 9p24.3-p23. Mutations in GLIS3 have been reported in association with Neonatal diabetes mellitus and hypothyroidism syndrome. We aimed to present a case of congenital diabetes mellitus congenital hypothyroidism associated with a newly identified mutation in the GLIS-3 gene.Case Report: A se...

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hrp0092p2-100 | Diabetes and Insulin | ESPE2019

Hypertriglyceridemia as a Complication of Severe Diabetic Ketoacidosis in Newly Diagnosed Diabetes - A case report

Hennig Matylda , Brandt-Varma Agnieszka , Luboch-Furmanczyk Monika , Mysliwiec Malgorzata

Introduction: In diabetes type 1 damage of pancreatic beta cells results in insulin deficiency and it can lead to many clinical and biochemical complications, including hypertriglyceridemia. Triglycerides level over 500mg/dl significantly increases the risk of acute pancreatitis which, in combination with ketoacidosis, can worsen the prognosis of patients.A case report: A 9 year old patient was admitted to the Pediatric ...

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hrp0092p2-101 | Diabetes and Insulin | ESPE2019

Evaluation of the Effect of Knowledge Levels of Adolescents Diagnosed with Type 1 Diabetes Melllitus on Hba1c and Life Quality Score

KESKIN Meliksah , YILDIRIM Nurdan , CETINKAYA Semra , AYCAN Zehra

Introduction: Type 1 Diabetes Mellitus (T1DM) is a chronic disease in children and adolescents.There are studies showing that quality of life is affected in T1DM. In our study, we aimed to evaluate the effect of diabetes knowledge levels on quality of life and metabolic status.Methods: Patients aged >10 years who were diagnosed with diabetes mellitus in our clinic and who were given diabetes education and who had reg...

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hrp0092p2-102 | Diabetes and Insulin | ESPE2019

Flash Glucose Monitoring System Versus Blood Sugar Test Strips: Cost Comparison and Satisfaction During a Year in a Northern Spain Region

Bertholt Zuber Maria Laura , Freijo Martin Concepción , Naranjo Gonzalez Cristina , Palenzuela Revuelta Inmaculada , Mariscal Sara Pozas

Background: The flash glucose monitoring system (FGMS) has been a great advance in quality of life for patients diagnosed with type 1 diabetes (T1D). However, it is a more expensive method.Objectives: To describe the characteristics of the pediatric population (<18 years) diagnosed with T1D using FGMS, during one year in our community. To assess the degree of satisfaction and possible inconveniences. To evaluate the ...

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hrp0092p2-103 | Diabetes and Insulin | ESPE2019

Evaluation of the Association of Glutamic Acid Decarboxylase Antibody and Limbic Encephalitis in Children with Type 1 Diabetes Mellitus

Ugurlu Aylin Kilinç , Bideci Aysun , Arhan Ebru , Döger Esra , Serdaroglu Ayse , Tekin Orgun Leman , Soysal Acar Azime Sebnem , Çamurdan Orhun , Cinaz Peyami , Gücüyener Kivilcim

Glutamic acid decarboxylase (GAD) is the enzyme that catalyzes the conversion of L-glutamat into GABA, one of the classical neurotransmitters with neuroinhibitory function. GAD is present in GABAergic neurons and in pancreatic beta cells. It is remarkable that Anti-GAD antibody(Anti-GADab) can have different disease manifestations, i.e., Type 1 diabetes mellitus (T1DM), Stiff-Person Syndrome, limbic encephalitis (LE), epilepsy. Cooccurence of T1DM and LE is reported in the lit...

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hrp0092p2-104 | Diabetes and Insulin | ESPE2019

Insulin Pump Therapy Implementation in Uzbekistan

Hanmehmet Khilola , Ibragimovich Ismailov Said , Usmanovna Alimova Nasiba

Background: Devices for continuous subcutaneous insulin infusion have become fundamentally new and progressive step in the treatment of diabetes.Aims and objectives: To evaluate the effectiveness of insulin pump therapy in comparison with the regime of multiple daily injections (MDI) of insulin.Materials and Methods: Forty children and adolescents with type 1 diabetes from 5 to 17 ...

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ESPE Abstracts

58th Annual ESPE

BiosciAbstracts