Background and Objectives: Recent studies demonstrated that a 1-hour post-load plasma glucose (1-h PG) value of ≥155 mg/dL during an oral glucose tolerance test (OGTT) is a new risk factor for predicting atherosclerosis. Herein, we evaluated whether individuals with normal glucose tolerance (NGT), whose 1-h PG is ≥155mg/dl, or with impaired glucose tolerance (IGT) have an increased carotid intimamedia thickness (CIMT), as compared with NGT individuals with 1-h PG <155 mg/dl.
Material and Methods: Obese adolescents at risk for prediabetes were administered a 75g OGTT. CIMT was measured in all patients on the same day with OGTT. Individuals with prediabetes were identified according to fasting plasma glucose concentration and/or HbA1C (5.7-6.4%). Patients with diabetes were excluded from the study. Subsequently, subjects were divided in 3 groups: that have NGT with a 1-h PG < 155 mg/dl, have NGT with a 1-h PG ≥155 mg/dl, and have IGT.
Results: The study included 171 obese adolescents with prediabetes (74 males, 97 females; mean age: 13.5 ± 1.8 years). Seventy-three patients were NGT with a 1-h PG < 155 mg/dl, 29 patients were NGT with a 1-h PG ≥155 mg/dl and 69 patients were IGT. No statistically significant difference was found between the groups in terms of age, weight, height and BMI (P> 0.05). As compared with NGT individuals with a 1-h PG <155 mg/dl, NGT individuals with a 1-h PG ≥155mg/dl exhibited higher CIMT (0.75±0.15 mm vs. 0.68±0.15 mm; P=0.025). No significant differences were observed in CIMT between IGT and NGT subjects with a 1-h PG ≥155 mg/dl (0.75±0.18 mm vs 0.75±0.15 mm; P>0.05). Of the three glycemic parameters, 1-h and 2-h PG, but not fasting glucose, were significantly correlated with CIMT.
Conclusion: These data suggest that a cutoff point of 155 mg/dl for the 1-h PG during OGTT may be a useful tool to identify a subset of individuals at higher risk of developing cardiovascular disease.
Key words: Prediabetes, obesity, 1-hour post-load plasma glucose, intima-media thickness
19 - 21 Sep 2019
European Society for Paediatric Endocrinology