ESPE Abstracts (2019) 92 P2-206

Growth Outcomes in Growth Hormone Treated Indian Children with Celiac Disease

Smita Ramachandran, IPS Kochar

Indraprastha Apollo Hospital, Delhi, India

Objective: To evaluate the height outcomes with growth hormone (GH)therapy during gluten fee diet in celiac disease (CD) associated with growth hormone deficiency in associated with isolated GHD.

Method: A retrospective study of 17 CD with growth hormone deficiency with 17 age and sex matched children with GHD were included in the study. Their pre and post treatment height and predicted height were evaluated.

Results: On analysis the mean weight in GHD was 28.7kg, CD was 28.37kg and the GHD group was shorter (124.67cm) at start than the CD group (128.46cm). The height velocity was better in the GHD group (10.3cm/yr), and 8.03ccm/yr in CD which was statistically significant. The mean predicted final height was better in the GHD 161.3cm and 158.1cm in CD. The Z score of PAH in GHD was -0.15 (SD 1.077), and in CD was -0.56 (SD 0.81) this was significant (P<0.001). The weight in GHD was 28.7kg and in CD was 27.3kg, but the final mean weight after treatment was 35.6kg and in CD was 43.6kg(P<0.03)

Conclusion: GHD and CD is a rare association and this is the first study from India analyzing the association with comparisons of the growth outcomes.

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