ESPE Abstracts (2019) 92 P2-71

Diabetes and Insulin

The Effect of Different Forms of Maternal Dysglycemia on the occurrence of Neonatal Hypoglycemia in babies admitted to NICU.

ASHRAF TAWFIK SOLIMAN, Husam Salama, Hilal Al Rifai, Sawsan Al-Obaidly, Mai Al Qubasi, Tawa Olukade

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Hamad Medical Centre, Doha, Qatar


Abstract: We report the effect of different forms of dysglycemia on the occurrence of neonatal hypoglycemia in a large cohort of pregnant women studied as a part of a PEARL-Peristat Study, funded by QNRF- Doha-Qatar

Methods: Out of 12255 pregnant women screened during 2016-2017, 3027 women were identified with gestational diabetes (GDM) (WHO criteria) and 233 were diabetic (DM) before pregnancy. All dysglycemic women were managed according to related guideline/protocol with 3 or more clinical visits during the pregnancy period. Neonatal hypoglycemia was defined as a plasma glucose level of less than 30 mg/dL (1.65 mmol/L) in the first 24 hours of life and less than 45 mg/dL (2.5 mmol/L) thereafter. Data on neonatal hypoglycemia for babies admitted to NICU was collected from the hospital records.

Results: Babies born to DM and GDM mothers required more admissions to NICU for various reasons ( 24.5 %, 15.96% and 11.9 % respectively (P < 0.01), Neonatal hypoglycemia in infants admitted to NICU occurred more frequently in babies of DM and GDM compared to non-diabetic women (45.6%, 18.6%, and 4.7% respectively). Neonatal hypoglycemia occurred more in babies < 36 weeks of gestational age (GA) versus those > 37 weeks of GA in non-diabetic women. However, neonatal hypoglycemia occurred more in babies born >37 weeks of age to DM ( 51.3%) and GDM (20.8%) when compared to babies born between 32 and 36 weeks of GA. Prolonged exposure to maternal Dysglycemia appears to stimulate more insulin secretion during in-utero life which is reflected more on the term and near-term infants.

Conclusion: Babies born to treated dysglycemic women are still prone to develop hypoglycemia more often than newborns of normoglycemic women. Full-term and near-term newborns delivered to mothers with treated dysglycemia had a higher prevalence of hypoglycemia compared to preterm newborns.

Volume 92

58th Annual ESPE meeting

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

European Society for Paediatric Endocrinology 

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