Introduction: Several factors contribute to the risk of neonatal macrosomia (NM) and its associated hypoglycemia (NH) in pregnant women.
Objective: To determine the prevalence of NM and its association with NH in a large cohort of normoglycemic and dysglycemic women.
Methods: Out of 12255 pregnant women screened during 2016-2017, 3027 women were identified with gestational diabetes (GDM) (WHO criteria) and 233 were diabetic (DM) before pregnancy. All dysglycemic women were managed according to related guideline/protocol with 3 or more clinical visits during the pregnancy period. Neonatal macrosomia (NM) is defined as an infant's birth weight of more than 4000 g at term. Neonatal hypoglycaemia (NH) was defined as a plasma glucose < 30 mg/dL in the first day of life and < 45 mg/dL thereafter. Data on neonatal outcome was collected the hospital records as a part of a PEARL-Peristat Study, funded by QNRF- Doha-Qatar.
Results: GDM and DM women had a higher prevalence of NM. In addition, macrosomic newborns of dysglycemic mothers had a higher prevalence of NH compared to MN of normoglycemic mothers. the major risk factors for macrosomia which were compared with the normal weight infant groups (for all parameters). (table)
|Macrosomia + hypoglycemia requiring NICU admission out of liveborn||0.078%||0.26%*||1.29%*|
|Macrosomia + hypoglycemia requiring NICU Admission out of all macrosomia babies||7 (1.57%)||8 (3.9%)*||3 (20%) *|
Conclusion: Neonatal macrosomia is still more prevalent in treated women with DM and GDM. It appears that macrosomic infants of dysglycemic mothers are in greater risk of having severe hypoglycemia requiring NICU admission compared to MN of normoglycemic women.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology