ESPE Abstracts (2019) 92 P3-115

Gender-Based Differences in the Clustering of Metabolic Syndrome Factors in Children and Adolescents

Valeria Calcaterra1, Corrado Regalbuto2, Federica Vinci2, Chiara Montalbano2, Giulia Dobbiani2, Annalisa De Silvestri3, Hellas Cena2, Daniela Larizza4

1university of Pavia and Fond. IRCCS Policlinico San Matteo, Pavia, Italy. 2University of Pavia, Pavia, Italy. 3Fond. IRCCS Policlinico San Matteo, Pavia, Italy. 4University of Pavia and Fond. IRCCS Policlinico S. Matteo, Pavia, Italy

Background: we depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, to identify early childhood prevention intervention and treatments.

Methods: We considered 1079 children and adolescents. According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI<75th, overweight BMI 75-95th and with obesity BMI>95th. MS was diagnosed when 3 of the following criteria for age and sex percentiles were met: BMI<95th, tryglicerides level>95th, HDL-cholesterol level<5th, blood pressure>95th percentile, fasting blood glucose>100 mg/dl and/or HOMA-IR >97.5th percentile.

Results: The prevalence of dismetabolic factors was similar in both genders, except for pathological BP, higher in males (P=0.02). MS was detected only in patients with obesity, with an higher prevalence in pubertal than pre-pubertal subjects (P=0.01), without any significant difference between gender. In prepuberty, the most common MS combination was obesity (HBMI)+hypertension (HBP)+hyperglycemia/insulin resistance (HGLY/IR) followed by HBMI+low HDL-levels (LHDL) + HGLY/IR versus HBMI+HBP+ HGLY/IR followed by HBMI+HBP+LHDL respectively in females and males. In pubertal period, the combination HBMI+HBP+ LHDL+ HGLY/IR was present in both genders.

Conclusion: we confirm that MS is an important consequence related to obesity, particularly in post-puberty stage. Some gender-based differences may be early considered in order to define specific preventive and treatment strategies.

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