ESPE Abstracts (2019) 92 P3-265

Plasma Asprosin Concentrations are Increased and Associated with Insulin Resistance in Children with Obesity

min wang, yanfeng xiao

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

Objective: Asprosin, a novel peptide that has recently discovered as an important regulatory adipokine, is relevant to obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of asprosin and explore its relationship to various obesity-related markers in children with obesity.

Methods: A cross-sectional study was conducted among 119 Chinese children, including 79 children with obesity and 40 lean controls. Anthropometric parameters, clinical data and circulating TNF-α, adiponectin, leptin and asprosin levels were measured.

Results: serum asprosin concentrations were significantly elevated in children with obesity compared with lean controls. Children with insulin resistance had higher asprosin levels than non-insuin resistance group. Asprosin was positively correlated with Waist-to-hip ratio (WHR), diastolic blood pressure (DBP), homoeostasis model of insulin resistance (HOMA-IR), leptin-to-adiponectin ratio (LAR), tumor necrosis factor-α (TNF-α) independent of their body mass index standard deviations score and age. In multivariable linear regression analysis, WHR and HOMA-IR were associated with the expression of asprosin.

Conclusions: serum asprosin are increased in children with obesity and associated with insulin resistance. It may be proposed as a novel marker to predict advanced disease.

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