ESPE Abstracts

In recent years, the problem of androgen deficiency as a factor in the formation of dyslipidemia, endothelial dysfunction, insulin resistance and systemic inflammation has been studied mainly in adult men, because the main cause of mortality and disability in this cohort is cardiovascular disease. However, there are practically no data on the relationships of sex hormones with lipid metabolism during hypoandrogenism (HA) during puberty.

Aim of research: was to analyze the effect of the degree of HA during puberty on lipid profile in boys with delayed puberty (DP).

Materials and methods: A comprehensive study of 75 boys aged 13-17 years with DP, including with the study of T in the blood by enzyme-linked immunosorbent assay, the level of which was determined by the degree of HA (ranging from 12.0 to 8.0 nmol/l - 1, in the range from 7.9 to 4.0 nmol/l - 2; less than 4.0 nmol/l - 3). The blood lipid spectrum was studied: total cholesterol (TC), β-lipoproteins (βLP), triglycerides (TG), high density lipoprotein cholesterol (HDL) in blood serum with the calculation of low density lipoprotein cholesterol (LDL) and atherogenicity coefficient (AC).

Results: In 59.1% of the examined, the presence of pathological changes in lipid parameters of atherogenic orientation (mainly type IIa dyslipidemia), an increase in the level of TC in 46.5%, βLP in 66.2%, LDL in 25.3%, and TG in 15.5%, which led to an increase in AC in 32.4% of patients. Changes in the atherogenic orientation in the lipid profile increased in proportion to the deficiency of androgens, with an increase in the degree of HA, a significant increase in the average values of TC, βLP, and LDL was noted. An analysis of the correlation relationships showed the existence of reliable negative relationships between the content of T and TC (r = -0.32, P = 0.008), βLP (r = -0.26, P = 0.03), which also confirms the effect of HA on the lipid profile.

Conclusion: In 59.1% of boys with DP, changes in the lipid profile were recorded, mainly due to the growth of proatherogenic lipid fractions, more pronounced with an increase in the degree of HA, which may indicate the effect of androgen deficiency in adolescents on lipid metabolism and is important for early diagnosis of disorders lipid metabolism, prevention of disorders of the cardiovascular system in future men.