ESPE Abstracts

Have a real increase in precocious and advanced puberty with COVID19? Retrospective observational analytical study in which we compared the incidence of first consultations made by early thelarchies between the months of March to December 2019 and between March and December 2020 at the Pediatric Endocrinology(PE)consultation in our hospital, and the increase in diagnosis of precocious puberty (PP)and advanced puberty (PA) in the cases evaluated for this reason, with the aim of demonstrating that the feeling that there has been in Primary Care as well as in the PD service about the increase in the incidence of these pathologies during confinement and the COVID season is real.77 patients who consulted for early thelarchy in 2019 (group1) and 99 in 2020 (group2). first consultation, difference between chronological age and bone age, sex hormone values (FSH,LH and estradiol) in the first analysis, if a functional test was performed to study the gonadal axis (Procrin) and result of the same, abdominal ultrasound, if they had received stopping treatment, if they had had contact with disruptors, if they had gained at least 3kg in weight in the last 6 months and the final diagnosis given.Comparing both years, in 2020 there were 28% more first consultations by early thelarchies than, in 2019 (p: 0.0001 average comparison). We therefore understand that there is a significant difference, observing a higher frequency of first consultations by early thelarchies in 2020 compared to 2019. In 2019 of the 77 consultations for precocious thelarchy, 18 were advanced puberty and 12 were precocious puberty, that is, 38.95% of the consultations for precocious thelarchy were diagnosed of an anticipation of physiological puberty; While in 2020 of the 99 consultations for this diagnosis, 35 were advanced puberty and 25 were precocious puberty, that is, of the total of patients with advanced thelarchies, 60.6% had an anticipation of normal puberty ; which implies an OR of 1.55. 0.002 Student’s t for samples We could say that in 2020 an acceleration of puberty has been seen regardless of age, increasing the incidence statistically significantly in both PP and AP. But we can also observe that in 2020 there are more children who consult with a higher BMI and with an increase in weight gain in the last 6 months. This increase in weight could suggest a trigger effect due to an increase in fat mass and a greater number of advanced puberty.