ESPE2022 Poster Category 1 Diabetes and Insulin (86 abstracts)
Introduction: Type 1 diabetes mellitus (T1DM) is characterized by insulin-producing pancreatic β-cells loss. Apo1/Fas, a glycosylated surface protein, is implicated in maintaining homeostasis of the immune system. Cytokeratin-18 (cCK-18) is a predictive marker of liver disorders in T2DM. Intercellular adhesion molecule-1 (ICAM-1) is considered a candidate gene for susceptibility to diabetes mellitus. Aim: To investigate the possible role of Apo1/Fas, cCK-18 and ICAM-1, in children and adolescents with T1DM. Materials and Methods: 49 children and adolescents with T1DM and 49 controls were included into the study. Somatometric measurements were obtained and the Body Mass Index (BMI) of the participants was calculated. White cell count and biochemical parameters were measured. Apo1/Fas, cCK-18 and ICAM-1 were measured using ELISA. The statistical analysis was performed using IBM SPSS Statistics 23. Results: Apo1/Fas (P=0.001), cCK-18 (P<0.001) and ICAM-1 (P<0.001) were higher in children and adolescents with T1DM compared to the controls. Apo1Fas was negatively correlated with glucose (P=0.042), uric acid (P=0.026), creatinine (P=0.022), total cholesterol (P=0.023) and LDL (P=0.005) in the controls. In children and adolescents with T1DM, Apo1/Fas was positively correlated with total cholesterol (P=0.013) and LDL (P=0.003). ICAM-1 was negatively correlated with creatinine (P=0.019) and positively with SGPT (P=0.014) in the controls, whereas in children and adolescents with T1DM it was negatively correlated with HbA1c (P=0.05). Conclusions: Apo1/Fas, ICAM-1 and cCK-18 may be useful as serological markers for monitoring for potential complications and long-term morbidity or mortality in children and adolescents with T1DM. Also, Apo1/Fas may have a protective role against metabolic complications in healthy children.
15 Sep 2022 - 17 Sep 2022