ESPE Abstracts (2022) 95 P1-63

ESPE2022 Poster Category 1 Fat, Metabolism and Obesity (73 abstracts)

Association of transient elastography and ultrasonographic fatty liver indicator in pediatric non-alcoholic steatohepatitis

Jong Seo Yoon 1 , Il Tae Hwang 1 & Eun Young Kim 2

1Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of South Korea; 2Chosun University School of Medicine, Gwangju, Republic of South Korea

Background: Transient elastography (TE) uses pulsed echo ultrasound to measure the hardness of the liver, showing excellent accuracy in the assessment of fibrosis, and is considered a useful test in nonalcoholic fatty liver disease (NAFLD). Ultrasound fatty liver indicator (US-FLI) is proposed as a non-invasive, semi-quantitative method for predicting hepatitis in children with NAFLD and may reflect the severity of liver histological changes. US-FLI ≥4 or 6 has been suggested as a predictive finding for NASH. These non-invasive imaging tests have been proposed to predict the diagnosis of NASH as an alternative to liver biopsy.

Objects: This study aimed to investigate the relationship between US-FLI and TE, which indicate the severity of NAFLD.

Methods: We enrolled 87 participants aged 11.42±2.19 years who were diagnosed with fatty liver on ultrasound. US-FLI is a scoring system ranging from 2-8, assessing the following items: liver/kidney contrast, posterior attenuation of ultrasound beam, difficulty visualizing the gallbladder wall, vessel blurring, difficult visualization of the diaphragm and areas of focal sparing. NAFLD is diagnosed with a minimum score of ≥2. TE was used to evaluate liver fibrosis in terms of liver stiffness measurement (LSM). The association between US-FLI and TE was analyzed by dividing into two groups using US-FLI ≥4 and ≥6 as predictive findings for NASH.

Results: The TE was significantly correlated in both NASH groups by US-FLI ≥4(r=0.251, P<0.019) and ≥6(r=0.376, P<0.001). As a result of univariate logistic regression analysis, TE was significantly associated with NASH diagnosed by US-FLI ≥4(OR 1.927; P=0.028) and ≥6(OR 3.277; P=0.003). In the receiver operating characteristic analysis, the TE showed good performance in detecting NASH diagnosed by US-FLI, with area under the curve [AUC] of 0.674(P=0.015) in NASH by US-FLI ≥4 and AUC of 0.794(P=0.004) in NASH by US-FLI ≥6.

Conclusions: TE is significantly associated with US-FLI in pediatric NASH. TE and US-FLI are expected to complement each other in the evaluation of the severity of NAFLD, and further studies are needed.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.