ESPE Abstracts (2022) 95 P1-487

ESPE2022 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (30 abstracts)

Early-Life Exposure to Phthalates in A Population of Infants from The North of Italy: Characterization and Time Trends

Laura Lucaccioni 1 , Elena Righi 2 , Viola Trevisani 1 , Erica Passini 1 , Lucia Palandri 2 , Patrizia Bruzzi 1 , Barbara Predieri 1 & Lorenzo Iughetti 1

1Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Background: Phthalates are ubiquitous environmental contaminants and endocrine-disrupting chemicals (EDCs). Nowadays, they are considered reproductive toxicants and in-utero exposure is well documented, although evidence of early life exposure is scarce, and needs to be described. Aim of this study is to assess phthalate exposure and its changes over the first months of life in a cohort of healthy full term infants and their mothers from a restricted area of the north of Italy.

Methods: Single-center, prospective birth-cohort study, assessing phthalate exposure in urine samples collected from mothers after the delivery and in their infants at birth(T0), 3(T3) and 6(T6) months. In infants, the collection was performed using phthalate-free bags. After solid-phase extraction, samples were analysed by triple Quad LC/MS Mass Spectrometry.

Results: 188 mother-infant pairs were enrolled. Data are summarised in the table. % represents the amount of positive detection (>LOD) for each sample. Significant associations between mother-infant pairs at birth were found for MMP, MEP, and MnBP. Significant relation in infant levels of phthalates at 3 and 6 months are represented by the ‘p’ column of the table, suggesting a continuative exposure to these chemicals during the indoor activities.

  T0 T0 T3 T6  
ng/ml % Mean (±SD) % Mean (±SD) % Mean (±SD) % Mean (±SD) P
monomethyl phthalate(MMP) 66 0.504±0.61 66 0.469±1.01 85 0.500±0.86 95 0.992±2.58 0.004
monoethylphthalate(MEP) 100 45.789±148.21 100 31.572±40.72 100 56.442±178.86 100 86.649±263.11 0.037
mono(2-ethylhexyl)phthalate (MEHP) 32 1.547±1.89 24 1.233±0.99 18 2.186±2.36 41 1.230±1.26 <0.001
mono-(2-Ethyl-5-hydroxyhexyl)phthalate(MEHHP) 98 3.370±10.29 94 2.331±3.44 94 1.282±1.56 99 4.016±5.27 <0.001
mono-(2-Ethyl-5-oxohexyl) phthalate(MEOHP) 100 2.629±5.91 98 1.626±2.66 98 1.189±1.43 100 3.243±3.64 <0.001
mono-n-butylphthalate(MnBP) 94 12.093±27.31 93 14.471±17.47 100 5.496±10.75 100 6.809±10.46 <0.001
monobenzylphthalate(MBzP) 99 3.648±3.28 99 6.673±8.35 94 2.322±6.40 98 2.555±3.58 <0.001

Conclusions: Phthalate exposure appears wide and extended over the first months of life. The exposure included phthalates more toxic and strictly regulated by the European Union that are still ubiquitous in unregulated consumers’ products. A long term follow-up for at-risk categories, as infants who spend long time in indoor activities, is needed to detect endocrine and neurodevelopmental effects. Our results suggest the need for public health preventive actions to protect vulnerable subjects.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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