ESPE2022 Poster Category 1 Thyroid (44 abstracts)
Relationships of urinary bisphenol A in childhood on thyroid hormone function in adolescents
Jung Eun Choi 1 , Eun Jeong Choi 1 , Seonhwa Lee 1 , Bohyun Park 1 , Hye Ah Lee 1 , Young Sun Hong 2 , Eunhee Ha 1 , Hae Soon Kim 1 & Hyesook Park 1
1Ewha Womans University Seoul Hospital, Seoul, Republic of South Korea; 2Ewha Womans University Mokdong Hospital, Seoul, Republic of South Korea
Purpose: Bisphenol A (BPA) is endocrine disrupting chemicals used to manufacture plastics such as epoxy resins and polycarbonate polymers. BPA has weak estrogenic and strong anti-androgenic effects and has also been linked to disruption of thyroid function in previous studies. This study aims to investigate the relationship between urinary bisphenol A exposure in early childhood and thyroid hormone of pubertal children in Korea.
Methods: From the Ewha Birth and Growth Cohort Study, who visited Ewha Womens Mokdong Hospital between 2001 and 2005 were included. The concentration of urinary BPA measured repeatedly for the same subject at 3-5 years old and 7-9 years old. We measured serum free T3, free T4 and thyroid-stimulating hormone (TSH) levels at 10-12 years in 128 out of 164 subject who repeatedly measured BPA concentrations at ages 3-5 and 7-9 years old. Prospective associations of thyroid hormone function in adolescents with bisphenol A exposure levels in childhood were assessed using generalized linear model analysis and P-value for trend was obtained. We also investigated the interaction of thyroid hormone changes due to exposure to BPA in two period.
Result: We found that levels of urinary BPA in age 3-5 years was not significantly associated with levels of thyroid hormone in 10-12 years old adolescents. We found that levels of urinary BPA in age 7-9 years was to be significantly related with free T3 levels in 10-12 years old in girls. In boys, no significant differences in thyroid hormone levels were observed by exposure to BPA. The association between urinary BPA and levels of the other thyroid hormones (TSH, Free T4) were not statistically significant. Free T3 concentration was significantly decreased with increasing BPA concentration in girls (β:-0.15 95%CI:-0.28~ -0.03).
Conclusion: In conclusion, BPA exposure in childhood affects thyroid function in adolescent girls. It might be related to increasing of thyroid disorder in adolescents according to environmental effects.
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