ESPE Abstracts

Objective: To investigate response to growth hormone (GH) treatment for idiopathic GH deficient (GHD) and family short stature (FSS) and Small for Gestational Age (SGA) patients or Combined group.

Design: GHD, FSS, SGA and Combined group patients who were currently receiving GH and had completed treatment with treatment duration of more than 6 months (from 8/2019 to 5/2021) at International Vinmec Central Park hospital. Measurements Growth hormone dose, change in height and growth velocity (GV) were recorded and compared. The effect of incremental dosing was assessed.

Result: A total of 31 pediatric patients with growth hormone deficiency (GHD) and 5 children with a combination of growth hormone deficiency and family short stature (GHD-FSS), and 2 children with a combination of growth hormone deficiency and small for gestational age (GHD–SGA), who received rhGH (recombinant human growth hormone) treatment were enrolled. There were no children with simple idiopathic short stature (FSS) or small for gestational age (SGA). At the beginning of treatment, chronological age, bone age, height, and BMI were statistically signifcant between the tree groups. rhGH dosage in GHD (0,042 ± 0,004 mg/kg/day) was signifcantly higher compared with GHD-FSS (0,038 ± 0,003 mg/kg/day) and GHD-SGA (0,03 ± 0,003 mg/kg/day). Height before and after GH hormone replacement therapy in 3 groups were: GHD group (before: 131 ± 15,4 cm, after: 138,5 ± 13,8) with the average duration of treatment in this group is 9,6 ± 6,2 months, GHD-FSS group (Before: 123,1 ± 16,7 cm, after: 130,8 ± 18,2 cm) with mean duration of treatment is 10 ± 3,5 months, GHD-SGA group (before: 116,5 ± 16,3 cm, after: 125 ± 16,3 cm) the average duration of treatment in this group is 12 ± 7,1 month) Height velocity after rhGH therapy was higher in the GHD group (0,91 ± 0,75 cm/ month) compared with the GHD-FSS group (0,76 ± 0,86 cm/ month) and GHD group (0,69 ± 0,65 cm/ month).

Conclusions: rhGH increases the height growth in children with idiopathic GH deficient (GHD), combination of growth hormone deficiency and family short stature (GHD-FSS), combination of growth hormone deficiency and small for gestational age GHD-SGA. height velocity after rhGH therapy was higher in the GHD compared with the GHD - FSS and GHD-SGA.