ESPE Abstracts

Background: Idiopathic short status (ISS) is defined as a height more than two standard deviations (SD) below the mean for age and sex and population group without evidence of systemic, endocrine, nutritional, or chromosomal abnormalities. Children with ISS have normal birth weight and GH secretion.

Aims: Aim of the study was to analyze the final adult height in a group of patients with idiopathic short stature.

Methods and patients: Inclusion criteria were:

• height below 3 pc,

• growth hormone secretion above 10 ng/ml in at least one of the two performed stimulation tests - after clonidine, glucagon, insulin, arginine or after the sleeping

• absence of chronic diseases that could be the cause of short stature, such as: celiac disease, inflammatory bowel diseases, cystic fibrosis, chronic renal diseases, decompensated hypothyroidism, asthma, hematooncological diseases, heart defects, autoimmune diseases of musculoskeletal system and exclusion of chronic glucocorticosteroids therapy

• Turner syndrome excluded and lack of signs suggesting other chromosomal abnormalities.

We evaluated the auxological data of 10 patients among 22 patients with ISS (8 girls and 2 boys) who completed the process of growth. Final adult height (FAH) was established when growth velocity was below 1 cm/year. X-rays of nondominant hand and wrist were evaluated using the Greulich and Pyle atlas. Predicted adult height (PAH) was estimated based on Bayley-Pinneau method.

Results: Mean FAH in the study group was 150,2 cm and mean final adult height SD score (FAH SDS) was -3,03. Target height SD score (TH SDS) in boys subgroup was 0,5 SDS and 0,7 SDS, in girls subgroup was from -2,0 SDS to 1,6 SDS, mean TH SDS in girls subgroup was -1,24 SD, none achieved target height. Corrected final height SD score (corr FAH SDS) was -2,15. Mean difference between FAH and TH (∆ FH - TH) was 12,4 cm, in girls subgroup was 10,4 cm, and in boys subgroup was 20,5 cm. Statistical analysis revealed positive correlation between FAH and TH (r=0,933, P<0,001) and between FAH SDS and TH SDS (r=0,901, P<0,001). Statistical analysis revealed positive correlation between FAH and PAH based on prepubertal bone age (r=0,945, P<0,001). Statistical analysis revealed also positive correlation between FAH SDS and height SD score (height SDS) at the age of 4 and 6 years.

Conclucions: Predicted adult height based on prepubertal bone age and height SDS at the age 4 years and 6 years can be helpful in estimating the final adult height.