ESPE Abstracts

Introduction: Patients with Turner syndrome (TS) diagnosed beyond the age of 12 years present a real challenge for therapeutic management. Indeed, compromises must be made between the progressive induction of puberty and an efficient treatment with growth hormone to have the best possible results.

Patients and methods: Our study concerns 18 cases of patients followed for ST in endocrinology consultation (CHU Constantine-Algeria).

Results: The reason for consultation was stunting in 12 cases, severe in 10 patients, and primary amenorrhea in 3 cases. Dysmorphic syndrome was found only in 3 patients. The mean age at diagnosis was 15 years and the mean bone age was 11 years. The karyotype identified a monosomy in 55% of cases and mosaics in the rest. Osteoporosis was found in 10 cases and growth hormone deficiency was associated with ST in 04 cases. Progressive estrogen therapy was concomitant with recombinant GH treatment in 14 patients (77%). The mean statural gain was 06 cm.

Conclusion: The late presentation of ST, with its bone consequences in particular, has become an increasing concern requiring simultaneous and multidisciplinary management. However, early diagnosis will allow better social integration, growth hormone may help to achieve a near-normal adult height and concomitant estrogen therapy will be beneficial for bone integrity and good sexual function.