ESPE Abstracts (2022) 95 RFC6.4

1Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), CONICET – FEI – División de Endocrinología. Hospital de Niños Ricardo Gutiérrez., Buenos Aires, Argentina; 2División de Hematología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina


Aim: To determine Sertoli cell function at diagnosis and after 3 months of chemotherapy.

Methods: A prospective cohort study was performed including children with acute lymphoblastic leukaemia, acute myeloid leukaemia, or non-Hodgkin lymphoma. Serum levels of AMH were evaluated at diagnosis and after 3 months during chemotherapy. Results were analysed as standard deviation scores according to pubertal stage and expressed as median (range).

Results: 93 boys, aged 6.09 yr (0.04-17.53) were included in the study, 75.3% were prepubertal at diagnosis, 73.1% with acute lymphoblastic leukaemia, 7.5% with acute myeloid leukaemia and 19.4% with non-Hodgkin lymphoma. Median AMH was -0.50 SDS (-2.07 to +6.27 SD) at diagnosis. Mean AMH was significantly different from a theoretical value of 0 SDS (P value <0.0001). 9.7% of the children had serum AMH below the 3rd percentile and 41.9% below the 25th percentile. After 3 months of chemotherapy, AMH was -0.30 SD (-1.74 to +5.00 SD), significantly higher than AMH at diagnosis (Wilcoxon matched pairs signed rank test, two tailed P value 0.0002), and not significantly different from a theoretical value of 0 SDS (P value 0.23). 3.2% of the children had serum AMH below the 3rd percentile and 30.1% below the 25th percentile.

Conclusion: Children with haematological malignancies have lower AMH concentrations compared to the reference population, reflecting a Sertoli cell dysfunction, at diagnosis. After 3 months of chemotherapy, AMH concentration increased significantly. The causes of the decreased function of Sertoli cells at diagnosis have yet to be determined.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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