ESPE2023 Free Communications Fat, metabolism and obesity 1 (6 abstracts)
Early corneal nerve loss in children with obesity and type 2 diabetes
Hoda Gad 1 , Hajar Dauleh 2 , Shiga Chirayath 2 , Maheen Pasha 2 , Basma Haris 2 , Rasha Amin 2 , Houda Afyouni 2 , Goran Petrovski 2 , Saira Shehzad 2 , Amel Khalifa 2 , Elwaseila Mohammed Ahmed 2 , Ghassan Mohamadsalih 2 , Judith Campbell 2 , Sari Jolkka 2 , Roshirl Biglang-awa 2 , Erlinda Cuatrona 2 , Gina Inso 2 , Gerald Razon 2 , Mohamed A. Hendaus 2 , Einas Elgassim 1 , Ioannis N. Petropoulos 1 , Georgios Ponirakis 1 , Rayaz A. Malik 1 & Khalid Hussain 2
1Weill Cornell Medicine-Qatar, Doha, Qatar. 2Sidra Medicine, Doha, Qatar
Background: Childhood obesity is highly prevalent in the MENA region and may be associated with sub-clinical neuropathy.
Methods: Children with obesity with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and Type 2 diabetes Mellitus (T2DM) and healthy controls (HC) underwent body composition analysis, assessment of vibration perception threshold (VPT), monofilament sensitivity and corneal confocal microscopy (CCM) to quantify corneal nerve fiber density (CNFD), branch density (CNBD), and length (CNFL).
Results: Sixty-nine children with obesity (NGT (n=40), IGT (n=13) and T2DM (n=16)) aged 14.0±2.9 years were compared to 20 healthy controls (HC). There was no difference in VPT or monofilament sensitivity between groups. There was no difference in CNFD, CNBD or CNFL between obese children with NGT or obese children with IGT compared to HC and obese children with IGT compared to obese children with NGT. CNBD (34.4(32.3-43.8) vs. 48.9(43.8-66.3), P=0.04) was significantly lower in obese children compared to healthy controls. Children with hidden obesity (high % body fat and low muscle mass) had a significantly lower CNFD (27.8±7.4 vs. 32.8±5.6, P=0.05) with no change in CNBD and CNFL compared to solidly built children. CNFL was non-significantly lower (18.0±4.2 vs. 20.5±4.5, P=0.094) in obese children with T2DM compared to HC and obese children with T2DM had lower CNFD (26.8±6 vs. 30.4±7.5, P=0.067) and CNFL (18±4.2 vs. 21.3±5.8, P=0.027) compared to obese children with NGT.
Conclusion: Children with hidden obesity and especially obese children with T2DM have evidence of early corneal nerve loss, indicative of sub-clinical neuropathy.
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