ESPE2023 Poster Category 1 Multisystem Endocrine Disorders (28 abstracts)
Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader-Willi syndrome
Mian-Ling Zhong 1 , Yu-Qing Cai 1 , Yan-Fei Tang 1 , Yang-Li Dai 1 , Yong-Hui Jiang 2 , Yan Ni 1 & Chao-Chun Zou 1
1Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China. 2Yale University, New Haven, USA
Keywords: Prader-Willi syndrome; Gut microbiota; Insulin sensitivity; Metagenomics sequencing; Obesity.
Aim: Obesity is the main driving factor for comorbidities in Prader-Willi syndrome (PWS) patients due to overeating behaviors. The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. The purpose of the present study is to characterize the fecal microbiota in Chinese patients with PWS and compare it to that of patients with obesity as well as healthy controls.
Materials and methods: We conducted a cross-sectional study with 35 PWS patients (PWS), 35 patients with obesity (OB), and 35 healthy controls (HC). Metagenomics sequencing were performed in stool samples.
Results: The compositions of fecal microbiota in PWS patients differed from that of participants in OB and HC group. It was characterized by increased Akkermansia Eubacterium, Eubacterium rectale, Roseburia intestinalis, and decreased Parabacteroides, Phascolarctobacterium. Additionally, homeostatic model assessment of insulin resistance (HOMA-IR) were lower in PWS patients compared to patients with obesity. The Spearman rank correlation analysis showed that Achromobacter, Acidiphilium, Xylophilus, and Frisingicoccus were significantly negatively correlated with HOMA-IR.
Conclusion: The compositions of gut microbiota in Chinese PWS patients differed from that of patients with obesity, which might contribute to higher insulin sensitivity in PWS patients.
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