ESPE Abstracts

Transversal study. Patients from 0 to 17 years of age who had undergone an analytical determination of 25OHD during the year 2021 in our hospital were collected. The following were contrasted: 25OHD, PTH, total calcium, age, sex, reason for requesting analysis, time of year and country of origin. 25OHD ranges: normal >30 ng/mL, suboptimal 20-30 ng/mL and deficit <20 ng/mL; and normal PTH: 9-60 pg/mL.

Results: 1. Prevalence of vitamin D deficiency: 2453 patients are included, 23.8% with normal 25OHD, 35.5% with suboptimal levels and 40.7% with deficit. The main causes of request for laboratory tests were endocrinological pathology, request in the context of another laboratory test, and changes in diet or weight. 56.5% are women and 43.5% men, with no significant differences in 25OHD levels (P>0.05). In the group of infants (0-2 years), 31.1% show deficits; however, in the group of adolescents (12-17 years old) this percentage increases significantly to 45.5% (P=0.01). In addition, in the first four-month period of the year, after the winter months, only 15.7% presented normal levels of 25OHD, in the second four-month period it rose to 29.1% and after the summer months, in the third four-month period, it reached 34.7% (P=0.01). 72.5% are Spanish, 13% from the Maghreb and the remaining 14.5% from other areas. A greater deficit of 250HD was observed in patients from non-European countries, presenting deficits in 62.7% (P=0.002), and the difference increasing significantly in patients from the Maghreb, with 68.8%. deficit (P=0.001). 1. Vitamin D and PTH: 599 patients are included. 24.3% with normal 25OHD, 36.3% with suboptimal levels and 39.4% with deficit. In the group of patients with normal 25OHD, PTH is elevated in 25.8%. In the group with suboptimal levels in 36%, and in the deficit group it reaches 44%. In addition, significant differences are observed by age groups: in 20% of infants with 25OHD deficiency, increased PTH is observed; however, in the group of adolescents with deficiency, an increase in PTH was observed in 40.7% of them.

Conclusions: The pediatric patients studied show a relevant and more prevalent vitamin D deficiency in winter, in adolescence and in children from non-European countries. This leads us to consider the need for vitamin D supplementation in winter for high-risk pediatric patients A relationship is observed between vitamin D deficiency and increased PTH levels, probably related to secondary hyperparathyroidism, being more evident in adolescents.