ESPE Abstracts

Keywords: Central precocious puberty; Luteinizing hormone; Precocious puberty Gonadotropin-releasing hormone agnosit test

Background: 2019 International consensus on central precocious puberty (CPP) proposed that random serum luteinizing hormone (LH) ≥0.83IU/L and < 0.2IU/L has important reference value for the establishment or exclusion of CPP, but there is no corresponding diagnostic criteria in China. This study aims to verify the cut-off value by comparing the differences in basic LH level between children with CPP or premature thelarche (PT).

Method: All of the study subjects were selected from hospitalized children with precocious puberty who visited the Children's Hospital affiliated to Zhengzhou University from 2020 to 2022, who were diagnosed by GnRH stimulation test and clinical manifestations. The clinical manifestations, laboratory data and imaging results of the subiects were retrospectively analyzed. LH peak ≥5IU/L and LH peak /FSH peak ≥0.6 in GnRH stimulation test is viewed as the gold standard to the diagnosis of CPP, comparing the cut-off values of serum LH basal value 0.83 IU/L and 0.2IU/L to analyze the diagnostic accuracy of serum LH basal value in the diagnosis of CPP.

Results: The study subjects include 203 girls with CPP and 149 girls with PT. Basal LH, FSH, LH/FSH and E2 in CPP group were higher than those in PT group, with statistical significance (P<0.05). There was a correlation between basal LH and LH peak after GnRH stimulation test and LH peak /FSH peak (P<0.05). When LH was 0.83IU/L, the sensitivity and specificity were 43.8% and 100%. When LH was 0.20 IU/L, the sensitivity was 87.7% and the specificity was 55.5%. When the cut-off value was 0.83IU/L, the breast Tanner stage, bone age, the difference between bone age and actual age, and pituitary height of CPP children with LH level ≥0.83IU/L were significantly higher than those of CPP children with LH level ＜0.83IU/L (P<0.05).