ESPE Abstracts (2023) 97 S1.2

ESPE2023 Symposia DSD (3 abstracts)

Studying neglected cell populations of the developing testis and their functions

Serge Nef

University of Geneva, Geneva, Switzerland

Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. The widespread adoption of advanced sequencing technologies, such as scRNA-seq, has provided the field of developmental biology with an opportunity to discover previously unrecognized cell types, such as short-lived progenitors or rare cell lineages. By combining single cell transcriptomic analyses during the critical period of sex determination with in vivo lineage tracing, we will describe the specification and differentiation of several previously neglected gonadal cell lineages that give rise to multiple cell types such as rete testis cells, peritubular myoid cells, as well as fetal and adult Leydig cells.

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

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