ESPE Abstracts

Endocrine and reproductive sequelae are among the most commonly reported complications in survivors of childhood cancer and brain tumors with nearly 50% individuals affected. Treatment related hormonal disorders may occur in a delayed fashion as late effects, several years to decades after the completion of cancer or tumor therapy, especially when resulting from the irradiation of the endocrine glands. This phenomenon requires a systematic, risk-based, approach in the screening of survivors in order to allow early diagnosis and treatment. Over the past two decades, several national and regional oncology-led consortia have sought to develop evidence-based long-term follow-up screening guidelines with a more recent effort to harmonize these recommendations through the collaborative International Guideline Harmonization Group. This presentation proposes an overview of the surveillance for endocrine disease in at-risk childhood cancer survivors, including areas of controversy and ongoing investigation.