ESPE Abstracts

Introduction: Subclinical left ventricular (LV) dysfunction may occur in chronic diseases such as type 1 diabetes mellitus (T1DM). For the patients at the early asymptomatic stage, LV reserve function is a sensitive index to detect subtle LV dysfunction. The purpose of our study is to assess the LV reserve function using treadmill exercise stress echocardiography (ESE) in children with T1DM.Method: The study was planned ...

Background: Hydroxychloroquine sulfate (HCQS) is an immunomodulatory drug used to treat various rheumatological conditions. However, its effect on preserving β-cell function in type 1 diabetes remains unclear.Objective: To determine the differences in C-peptide (fasting and post mixed meal) and HbA1c in children with new-onset T1D on hydroxychloroquine therapy versus placebo.Methods:</...

Background: Nail-fold capillaroscopy (NFC), a non-invasive tool that can detect microvascular changes, has recently gained popularity in the diabetes field as a warning sign before the development of diabetes-related complications.Objective: We aimed to assess capillary microarchitecture in children with type 1 diabetes mellitus (T1DM) by comparing them with a healthy control group.Subjects...

Introduction: Obesity is associated with an increased risk of developing several metabolic disorders, such as type 2 diabetes. The Children’s Lifestyle Medicine Centre at the Jeroen Bosch Hospital is a national reference center for the personalized treatment of children (aged 5-18 years) with severe obesity. As part of this personalized program, patients undergo an extensive oral glucose tolerance test (OGTT), in which both glucose and insulin levels are...

Background: Lanreotide, a prolonged-release somatostatin analogue, has been utilized off-label for nearly a decade to treat cases of congenital hyperinsulinism (CHI) that do not respond to diazoxide. Acute side-effects of Lanreotide include diarrhoea and topical allergic reactions. Long-term effects include hepatitis, gallstones, growth suppression, hypothyroidism and gastrointestinal dysmotility. However, limited number of case series have documented the long...

Background: Congenital hyperinsulinism (HI) is a group of insulin secretion disorders with highly heterogeneous genetic aetiologies, which may significantly impact on treatment and follow-up. Genetic diagnosis is unsolved in up to 50% of the individuals, but the benefits of retesting including all the recent genetic discoveries has not been previously assessed.Aim: We examined the effectiveness of rescreening the known H...