ESPE Abstracts

Studies of patients with hypogonadotropic hypogonadism or delayed puberty have identified genes whose encoded proteins are important for GnRH neuronal development and/or stimulation of GnRH secretion to trigger puberty onset. Notably, the neuropeptides, kisspeptin and neurokinin B, produced in hypothalamic neurons upstream of GnRH neurons, were identified as key activators of pulsatile GnRH secretion. However, the mechanisms restraining GnRH secretion during childhood to preve...