ESPE Abstracts

Introduction: The population study of early detection of type 1 diabetes (T1D) in asymptomatic children in the Podlaskie region of Poland is an extension of the Pre-d1abetes Study conducted by our clinic between 2019 and 2023 in collaboration with 14 Polish diabetes centres. A total of 1288 patients aged between 7 months and 18 years were studied with positive family of T1D. Positive 3-screen ELISA values were observed in 112 patients (8.69%). During analysis ...

Introduction: Polycystic kidney and diabetes syndrome (PCKDD) is an autosomal dominantly inherited disorder caused by HNF-1B mutations associated with a heterogeneous multisystemic phenotype mainly affecting kidney and pancreas, resulting in highly variable nephropathies, and frequently, diabetes diagnosed before the age of 25 yrs. Pancreatic hypoplasia, malformations in the genital tract and hepatic dysfunction may also be observed.<str...

It is unknown whether the glucagon-like peptide-1 (GLP-1) receptor agonists have a significant protective effect against acute islet injury. This study investigated the protective effect and mechanism of liraglutide on acute islet injury induced by low doses of streptozotocin (STZ). The results showed that liraglutide pretreatment preserved the structural integrity of pancreatic islets, improved insulin levels and glucose tolerance, and significantly reduced the incidence of d...

Objective: To investigate the prevalence of elevated arterial stiffness and associations to known and potentially novel risk factors in a modern European technology-based cohort of children and adolescent with type 1 diabetes.Research Design and Methods: Cross-sectional study including 127 children recruited from Pediatric Diabetes Departments across Eastern Denmark between May 2022 and January 2024. Arterial stiffness w...

Introduction: Peripheral diabetic neuropathy (PDN), clinical or subclinical, of large-diameter nerve fibers or small-diameter nerve fibers is a common complication of type 1 diabetes mellitus (T1DM).Aims: Early detection of the prevalence of subclinical PDN by assessing the function of small and large nerve fibers in children and adolescents with T1DM.Methods: The study included 53...

Exercise-induced hyperinsulinism is a hypoglycaemic disorder characterised by inappropriate insulin secretion following anaerobic exercise. Activating promoter mutations in the MCT1 gene (SCLA16A1), located on 1p13 coding for monocarboxylate transporter 1 (MCT1), is shown to associate with EIHI. A 2 year old girl presented with hypoglycaemic seizures following a brief period of viral illness with reduced oral intake. Investigations revealed non ketotic hypoglycaemia with a blo...

Introduction: Early onset diabetes mellitus (DM) presents a challenge in pediatric clinical settings, often necessitating comprehensive genetic investigation to understand underlying causes and tailor management strategies. This study aimed to elucidate the genetic basis of early onset DM through whole exome sequencing and assess its clinical relevance.Methods: Between July 2022 and May 2024, we conducted a prospective s...

Introduction: Diabetic nephropathy (DN) is one of the most frequent and severe complications of diabetes mellitus and a leading etiological cause of chronic kidney disease. Early diagnosis and treatment are essential to prevent further deterioration of kidney function. Albuminuria has been considered to be the clinical hallmark of diabetic kidney disease and is used for its diagnosis and follow-up. Although microalbuminuria is a marker established in the clini...

Background: Wolcott-Rallison syndrome is a rare autosomal recessive condition. It is characterized by neonatal or early-onset, non-autoimmune insulin-dependent diabetes, spondyloepiphyseal dysplasia, renal or hepatic failure and growth retardation.Objective: We are reporting a novel homozygous pathogenic mutation in the EIF2AK3 c.1277T>A p. (Leu426*) in a Pakistani child who presented with neonatal diabetes, ...