ESPE Abstracts

Objectives: Characterizing the children’s and their caregivers’ sleep patterns and disturbances in children with Type 1 Diabetes Mellitus (T1DM) can improve diabetes management and outcomes. Therefore, we aimed to examine the associations between sleep quality in children with T1DM and metabolic outcomes namely, haemoglobin A1c, time in range.Method: This is a prospective cohort study included children with T...

Introduction: Monogenic diabetes accounts for approximately 3.5% of patients manifesting diabetes till 30 years. Majority of these patients had subtypes of Maturity-Onset Diabetes of the Young (MODY) caused by disruption of the genes encoding glucokinase (GCK), hepatocyte nuclear factor 1-alpha (HNF1A) or 4-alpha (HNF4A), respectively. However, also rare forms of monogenic diabetes could be detected particularly thanks to massive par...

Introduction: The most common non-metabolic complication of insulin pump therapy is set occlusion, and the literature on factors associated with occlusion is limited. This study aims to investigate the factors influencing set occlusion.Methods: A total of 52 patients with type 1 diabetes using insulin pumps were included in the study. A 36-item questionnaire related to set occlusion was administered to the healthcare per...

Introduction: ‘Maturity-Onset Diabetes of the Young ‘(MODY) 9 is a rare subtype of MODY, resulting from mutations in the ‘Paired Box Gene 4’ (PAX4) on chromosome 7q32.1. PAX4 is mainly expressed in pancreatic islet cells, playing a crucial role in the development, differentiation, proliferation, and survival of insulin-producing β-cells during embryonic stages, as well as in β-cell regeneration in adulthood. Mutations in PAX4 ...

Introduction: Adolescents with type 1 diabetes mellitus (T1D) may differ from their healthy peers in respect to sexually transmitted diseases (STDs) knowledge and contraceptive use.Objectives: We aimed to explore sexual knowledge and contraceptive use and associated factors in T1D adolescents compared to healthy peers.Methods: Fifty-eight T1D adolescents (mean±SD age 16.3±2.0...

Background: Woodhouse-Sakati syndrome (WSS) is a rare, autosomal recessive genetic disorder with variable clinical manifestations mainly affecting the endocrine and nervous systems. Diabetes mellitus is one endocrine manifestation but there are no comprehensive data on the epidemiology, clinical features, underlying mechanisms, and management, particularly within the Qatari population.Methods: This retrospective study wa...

Background and Purpose: Previous studies have shown that autoimmunity in patients with type 1 diabetes mellitus (T1DM) begins long before the onset of clinical manifestations. Viruses, such as Coxsackie virus, play an important role in the complex and multifactorial etiology of T1DM. Human hair grows by 1 cm per month. A variety of endogenous molecules such as proteins, metabolites and hormones are incorporated during hair growth, so that a hair sample can pro...

Background: Type 1 diabetes (T1D), as one of the most common chronic autoimmune diseases, can have significant negative impact on pubertal development and overall reproductive health. Girls with T1D have been reported with delayed onset of menarche, in relation to premenarchal onset of T1D, inadequate metabolic control, insulin dosage, and duration of diabetes.Methods: We conducted a retrospective cross-sectional single-...

Introduction: Currently in Ireland, the majority of children are admitted to hospital for education at initial diagnosis, regardless of diabetic ketoacidosis (DKA) status. ISPAD 2022 suggests that outpatient management for metabolically stable patients is a feasible management option if adequate resources are available. This study assesses the feasibility of such management in the University of Limerick (UHL) Paediatric Department by quantifying the care and e...