ESPE Abstracts

The ATP-sensitive potassium (KATP) channel couples beta cell electrical activity to glucose-stimulated insulin secretion. Loss-of-function variants in either the regulatory (sulfonylurea receptor 1, encoded by ABCC8) or the pore-forming (inwardly rectifying potassium channel 6.2 [Kir6.2], encoded by KCNJ11) subunits result in congenital hyperinsulinism (CHI), whereas gain-of-function mutations cause neonatal diabetes. Patients with two recessive loss-of-funct...

Background: Diazoxide (DZX) is the first-line drug for congenital hyperinsulinism (CHI). DZX-unresponsiveness is common in patients with ATP-sensitive K (KATP) channel (ABCC8, KCNJ11) gene abnormalities. However, even in KATP channel abnormalities, when pathological variants are found only in the paternal allele, the pancreatic lesions may be localized and radically resectable, and genetic analysis may be helpful. Some reports summarizing the genetic ...

Background: The alarming increase in the prevalence of obesity in children and adolescents following COVID-19 pandemic has given rise to an upward trend in Type 2 Diabetes.Aims/Objectives: To determine the prevalence of newly diagnosed Type 2 Diabetes in children and adolescents from the year 2018 to 2022.Methods: A hospital based retrospective study was conducted in the Paediatric...

Background: There is an urgent need for better detection of early subclinical manifestations of microvascular complications of diabetes such as peripheral neuropathy (DPN), which already occur in children. The gold standard for the diagnosis of DPN is the measurement of nerve conduction velocity (NCV), which, however, can only detect changes in the large myelinated fibres. At the initial stage of DPN, small, unmyelinated nerve fibres are damaged. High-resoluti...

Background: Neonatal diabetes mellitus (NDM) is a rare monogenic disorder that typically occurs within the first 6 months of life. However, there is limited information from India about the clinical characteristics, treatment, and long-term outcomes for children with NDM. This study aims to provide a comprehensive overview of one of India's largest cohorts of children with NDM. These children were treated at a single referral center in North India over a ...

Background and Aims: Insulin pump therapy may o"er superior glycemic control compared to multiple daily injections (MDI) in specific populations. Closed-loop insulin delivery systems show promise but have limited data in the Saudi pediatric and young adult populations. This study aimed to evaluate the e#cacy of insulin pump therapy in children with type 1 diabetes previously treated with multiple daily injections.Methods:</s...

Background: Single gene variants that give rise to neonatal diabetes mellitus (NDM), maturity onset diabetes of the young (MODY) and syndromic forms of diabetes mellitus (SDM) are responsible for 3.1-4.2% of all diabetes cases. Next generation sequencing techniques (NGS) are the game changer in terms of accurate diagnosis of monogenic diabetes (MD) which in turn allows the most appropriate treatment and the more precise prognostics. This single-center study wi...

Introduction: Secondary diabetes (drug-induced and related to diseases of pancreas) increases the burden of care of patients, associated with less favorable outcomes. For many medications, most evidence comes from case reports or extrapolations of adult data and this condition is poorly documented as priority is given to the primary disease. Here we aimed to describe the patients diagnosed as secondary diabetes in our clinic and present the long-term follow-up...

Background: Cardiovascular complications are the leading cause of mortality and morbidity in patients with type 1 diabetes (T1D), and early assessment is crucial. Our study aimed to determine the impact of diabetes on vascular health by monitoring 24-hour ambulatory blood pressure (ABPM) and measuring arterial stiffness (AS) in children with T1D.Methods: Seventy-four consecutive children with T1D and 68 age and sex-match...