ESPE Abstracts

Aim: This experimental study is to investigate the effects of excessive fructose consumption on body weight, omental fat, insulin resistance, lipid profile and lipid peroxidation.Materials-Methods: In this study, 18 mature, albino, male Sprague Dawley rats (aged 8 weeks, weighing 200–220 g) were included in our study. They were fed ad libitum, housed in pairs in steel cages, and kept in a temperature-controlled env...

NASH is an increasingly relevant finding in the pediatric population affected by obesity. In adults, the evolution of this steatosis towards fibrosis and correlation with metabolic syndrome is increasingly significant. The existence of a rapid and validated in-office screening tool would be very useful.Main Objective: To evaluate whether the measurement of intraperitoneal fat measured through nutritional ultrasound allows for the diagnos...

Background: Aspartate transaminase-to-platelet ratio index (APRI) is an easy and useful predictor of hepatic fibrosis in patients with chronic hepatic disease, and it significantly correlates with the degree of hepatic fibrosis in adult patients with non-alcoholic fatty liver disease (NAFLD).Objects: This study aimed to evaluate the use of APRI in assessing the severity of NAFLD in children and adolescents.<p class="...

Background: Melanocortin4-receptor (MC4R) deficiency is the most common cause of monogenetic obesity. Other forms of genetic obesity, like 16p11.2 deletion syndrome, are associated with increased head circumference (HC). Little is known about HC in patients with MC4R deficiency.Methods: This study included patients with homozygous or heterozygous, pathogenic or likely pathogenic ACMG class 4 or 5 MC4R variants. Pediatric...

Introduction: The World Health Organization (WHO) European Regional Obesity Report 2022 stated that obesity rates have reached epidemic proportions across the European Union (EU). Obesity affects nearly one in three children (29% of boys and 27% of girls), and is associated with adverse psychological and psychosocial outcome and increased risk for noncommunicable diseases (NCDs). In addition, none of the 53 Member States are on track to meet the target of stop...

Introduction: There is a close relationship between cardiovascular disease and diet. While cardiometabolic risk has been demonstrated in adolescents with obesity, there is little information on the advanced lipoprotein profile (ALP) in adolescents with anorexia nervosa and low body weight.Objective: To evaluate the metabolomic-nutritional and cardiac profile in three groups of adolescents: 1. anorexia nervosa and low bod...

Introduction: Familial hypercholesterolaemia (FH) is a frequent (1:300) autosomal dominantly inherited condition which causes premature cardio–cerebrovascular disease (CVD). Early detection and treatment can prevent the development of CVD and premature death. Our pilot study aimed to investigate the feasibility and efficacy of a screening based on a capillary blood test performed during a school medicine visit.Methods:</str...

Introduction: The prevalence of overweight and/or obesity is approximately 2 times higher in people with intellectual disability (ID). Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder linked to hypothalamic dysfunction. People with PWS display ID and a characteristic nutritional trajectory ranging from anorexia to hyperphagia, leading to early severe obesity. Other rare diseases with ID are associated with eating disorders and overweight. Toda...

Aim: to assess telomere length (TL) changes and sleep quality in patients with abdominal obesity after a lifestyle intervention.Patients, Material and Methods: 122 patients with abdominal obesity, aged 7-16 years, were included in a control randomized intervention study (NCT031472). Abdominal obesity was diagnosed using the waist circumference. The intervention included a 2-month intensive phase and follow-up at 12 and 2...

Background: due to the well-known association between intestinal permeability and obesity, zonulin has been recently proposed as an indicator of intestinal mucosal barrier integrity. Nevertheless, data about zonulin are extremely scarce in pediatric age.Objectives: aim of this study was to investigate the relationship between serum and faecal zonulin levels with body mass index (BMI) and biochemical markers of insulin re...