ESPE Abstracts

Introduction: Exosomes are extracellular vesicles whose cargo includes proteins that may influence the function of distant cells. It is unknown, however, whether there are differentially expressed proteins (DEPs) in the circulating exosomes of appropriate- vs small-for-gestational-age (AGA vs SGA) infants at birth and, if so, whether such DEPs relate to measures of endocrine-metabolic health and body composition in childhood.Subj...

Background: Obesity in childhood and adolescence represents one of the most challenging public health problems of the 21st century owing to its epidemic proportions worldwide.Aim: The aim of our study was to determine the concentrations of apelin-12, vaspin and resistin in children and adolescents with overweight and obesity before and 1 year after the implementation of a lifestyle intervention program of diet, sleep and...

Introduction: Rapidly rising rates of childhood obesity (CO) are a current problem, and European and national data confirm the concern. CO comorbidities occur early and tend to persist into adulthood, negatively affecting long-term health. There is an urgent need to implement CO prevention programs, starting in the early years of life. In Southern Italy, an innovative health project, “EpPOI: Educate to Prevent Childhood Obesity,” has been establish...

The genotype-phenotype relationship in PWS patients is important for a better understanding of the clinical phenotype and clinical characteristics of different genotypes of PWS in children. We aimed to explore the influence of specific gene changes on the clinical symptoms of PWS and the value of early screening and early intervention of the condition. All data in this study were extracted from the database of the XiaoPang Weili Rare Disease Care Center. The collected informat...

Introduction: Both the detrimental effects on health produced by obesity, and the burden provoked on healthcare systems clearly dictate the need to provide nutritional interventions for preventing and managing obesity during childhood. Furthermore, the lifestyle habits developed in early childhood have a long lasting effect on cardiovascular and metabolic health, highlighting the importance of prevention. PODiaCar project is dedicated to enhancing the efforts ...

Introduction: Polycystic ovary syndrome (PCOS) prevalence varies widely, ranging from 2.2 to 20%, depending on the diagnostic criteria and the studied population. This condition increasingly affects adolescents, potentially affecting around 3-11% of girls. In three forth women with PCOS obesity is present, with elevated prevalence of central distribution of adipose tissue - a significant risk factor for various metabolic disorders. Recent studies have focused ...

Aim: To evaluate whether a straightforward assessment like the Six-Minute Walking Test (6MWT) can effectively gauge the impact of an online supervised training program on lipid and glucose metabolism in a cohort of children with obesity, given the efficacy of exercise-based interventions in influencing the pathogenic processes underlying obesity-related complications.Methods: A group of 35 Caucasian children aged 8-13 wi...

Introduction: Children and adolescents with a body mass index (BMI) greater than the 98th centile are at an increased risk of complications including cardiovascular and liver disease and type 2 diabetes mellitus. Currently, lifestyle modification is the first line intervention. Pharmacotherapy, such as liraglutide and semaglutide, has recently been licensed for adolescents greater than 12 years of age. This study aimed to compare the impact of pharmacotherapy ...

Introduction: This retrospective, cross-sectional study utilizes South Korea’s KNHANES database from 2007 to 2020 to investigate the additive impact of parental metabolic syndrome (MetS) on their offspring and to determine if this varies depending on the gender of the child.Method: The study population was narrowed down to 5,245 participants and was divided into gender groups. Each gender was further divided into t...

Background: Central obesity in children is a significant risk factor for cardiovascular diseases, potentially more critical than BMI-defined obesity, and can persist into adolescence and adulthood. Measuring the Waist-to-Hip Ratio (WHR), an indicator of central obesity and associated health risks, typically requires direct measurement with a tape, which can be inconvenient and socially unacceptable. Therefore, non-contact anthropometric techniques to measure b...