ESPE Abstracts

Premature adrenarche (PremA), is associated to increased adiposity and in girls to earlier puberty and adverse metabolic profiles. Recently, the use LC-MS/MS studies demonstrated adrenal production of more potent androgens:11-oxygenatedC19 steroids. Defining the mechanisms that regulate adrenal C19 steroid production has been elusive. We recently showed that genetic determinants of DHEAS during adrenarche differed from those identified during adulthood. One top variant was at ...

The steroid constellation in affective disorders suggests a stress-related pathogenesis or response and may pave the way for novel therapeutic strategies. In adolescents, previous studies have identified hypothalamic-pituitary-adrenal (HPA) axis dysregulation with hypercortisolemia. However, evidence so far is limited to a subset of the steroid spectrum, predominantly focusing on glucocorticoids. In order to gain a more holistic understanding, we analyzed urine metabolites of ...

Objectives: Hyperphagia and severe obesity may result from impaired melanocortin-4 receptor (MC4R) signaling due to rare biallelic variants in POMC or PCSK1 (proopiomelanocortin [POMC] deficiency) or LEPR (leptin receptor [LEPR] deficiency), Bardet-Biedl syndrome (BBS) or acquired hypothalamic obesity (HO). Previously, setmelanotide in patients aged 2-17 years was well tolerated and improved weight-related measures and hunger severit...

Background: The integration of mobile health technology with a limited number of physical visits shows promising treatment outcomes, but long-term evidence is lacking. Additionally, concerns about eating disorders following obesity treatment are common among families and caregivers, although data on this matter are scarce for children and adolescents. This study evaluates three-year weight outcomes for patients using a digi-physical treatment tool and reviews ...

Objective: To evaluate the severity and the correlates of depressive symptoms in adolescents with obesity comparing to normal adolescents in Hong Kong using a validated screening tools: Patient Health Questionnaire-9 (PHQ-9) for age 11-17 in Hong Kong.Methods: In this prospective and retrospective cross-sectional study. We recruited 840 adolescents, including 306 adolescents with obesity from clinic and local schools. We...

Introduction: Metreleptin is a leptin replacement therapy used as an adjunct to diet to treat the metabolic complications of leptin deficiency in lipodystrophy, a rare disease characterised by loss of adipose tissue. Previously, identification of T-cell lymphomas in three metreleptin-treated patients with acquired generalised lipodystrophy (AGL) led to concerns of a potential link between metreleptin and lymphoma development.Meth...

Objective: To explore the diagnostic value of morning urinary gonadotropins for assessing central precocious puberty (CPP) in girls with varying BMI and the potential use of first morning voided urinary luteinizing hormone (FMV ULH) in monitoring CPP treatment.Methods: A total of 335 precocious puberty girls were selected. Data of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), gonadotropin-releasing ...

Purpose: To investigate the incidence of central precocious puberty and the effect of being overweight or obese before age 6 on the development of central precocious puberty (CPP) in Korea.Method: National health insurance data of all children in South Korea aged 0-9 between 2012 and 2020 were examined to investigate the incidence of CPP. CPP was defined as cases in which a patient, diagnosed with CPP, received treatment...

Background: Polyuria-polydipsia syndrome (PPS) is a common condition in children, and its etiology is not always easily elucidated. Although the water deprivation test remains the gold standard for diagnosis, its limitations necessitate the search for alternative diagnostic methods. Due to its stability, copeptin is a valuable current parameter that is considered more reliable than AVP measurement. This study aims to compare copeptin levels between patients wi...

Introduction: The management and follow-up of paediatric patients with arginine vasopressin deficiency (AVP-D) is challenging, particularly in infants (0-2 years). Few studies have examined the particularities of AVP-D in this age group.Objectives: To describe clinical, laboratory, and demographic characteristics of AVP-D in infants at diagnosis and to describe the follow-up during the first years of life. To ascertain c...