ESPE Abstracts

Objectives: The gonadotropin-releasing hormone (GnRH) analogue triptorelin is used to treat central precocious puberty (CPP) in 1-, 3- and 6-month prolonged-release (PR) formulations. Currently, only the 1- and 3-month formulations are approved for CPP in China. However, the 6-month formulation is available for CPP treatment in numerous countries; this study assessed the efficacy and safety of this formulation in Chinese children with CPP.<p class="abstext...

Background: Objective to determine the efficacy of short-term rhGH treatment on metabolic indices in TGHD patients by comparing the changes in blood glucose and lipid levels before and after rhGH replacement therapy.Methods: The levels of metabolic indices (AST, ALT, TC, TG, HDL-C, LDL-C, FBG, GA, and URIC) in their basic state in TGHD patients were recorded, and differences in these levels between the TGHD and control g...

Background: Recent studies suggest an association between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1). Particularly, considering the intricate interplay among α-Klotho, sex hormones, and IGF-1 during puberty, investigating α-Klotho levels in patients with central precocious puberty (CPP) could provide a deeper understanding of the significance of this protein.Methods: A total of...

Background: Isolated gonadotropin-releasing hormone deficiency (IGD) is a genetically heterogeneous disorder caused by >60 genes resulting in a broad range of clinical manifestations and classified into Kallmann syndrome (KS) with anosmia and normosmic isolated hypogonadotropic hypogonadism (nIHH). Despite the advent of next-generation sequencing technology, ~50% of the cases remain genetically undiagnosed. Previously, copy number variations (CNVs) in known...

Introduction: Differential diagnosis of partial central diabetes insipidus (PCDI) and primary polydipsia (PP) is challenging. Copeptin, a stable biomarker derived from the vasopressin precursor peptide, increases in response to arginine infusion. This has been utilized to distinguish between central diabetes insipidus (CDI) and PP, with a cutoff of 3.8 pmol/L at 60' post-infusion in adults.Objective: Evaluate argini...

Aim: Aromatase inhibitors are widely used in clinical practice and are currently employed in the treatment of adolescents with short stature. However, the impact of these inhibitors on the reproductive function in male adolescents remains unclear.Methods: The data of patient with short stature who had completed aromatase inhibition therapy between 2015 and 2022 at the First Affiliated Hospital of Zhejiang University Scho...

Background: Defects of MKRN3, DLK1, KISS1, and KISS1R and some disorders, such as Temple syndrome (TS14), cause central precocious puberty (CPP). Furthermore, MECP2 was reported as a causative gene for CPP in 2023. To our knowledge, comprehensive studies on (epi)genetic abnormalities, clinical features, and hormonal features in patients with CPP have not been reported.Methods: In 90 CP...

Introduction: Pituitary stalk interruption syndrome (PSIS) is a rare congenital disorder characterized by absent, thin, or interrupted pituitary stalk, absent or ectopic neurohypophysis, and hypoplasia or aplasia of the adenohypophysis. It often accompanies midline abnormalities and diverse endocrine dysfunction, with its etiology largely unknown. Recent reports have linked mutations in the ROBO1 gene to PSIS.Aim: To des...

Background: Neuroendocrine disorders after traumatic brain injury (TBI) are found in 30-70 % of adults after TBI as reported 2011 in a German study with 1242 patients. Consecutive hormonal dysfunction may markedly impair thyroid and adrenal gland functions, which may put patients at risk if it remains unrecognized. Unfortunately, in the German database no children were included. However, endocrine disorders after SHT are also found in children, as the internat...