ESPE Abstracts

Background: International guidelines recommend specialised medical and psychosocial care for people with DSD by multidisciplinary teams in designated centres. The DSDCare project, funded by the German Federal Ministry of Health from 05/2020-08/2023, aimed to implement a standardised care model for people with DSD, and evaluate quality of care in 10 centres in Germany.Methods: Initially, quality indicators for structural,...

Background & Aim: The national Danish assessment and hormone treatment program for transgender adolescents started in 2016 and follows international guidelines. We aim to investigate the effects of hormone therapy on the sex steroid metabolite profile and gonadotropins.Methods: This observational study includes 219 transgender adolescents who started hormone therapy before 18 years of age comprising 55 individuals as...

Background: Gender role behaviour refers to a set of behaviours that differ for boys and girls, although its source and development remain controversial. Gender differences in the choice of toys and activities are observed as early as 12 months. Ad hoc tests, such as the Toy Preference Test (TPT), have been developed to highlight gender differences in paediatric populations. The aim of our study was to investigate play behaviour, to determine which toys are mo...

Introduction: As of May 2021, German law protects children with differences of sex development (DSD), including females with congenital adrenal hyperplasia (CAH), from non-consensual genital surgery. Parents can consent only in emergencies; all other surgeries require the child's consent. Exceptions are allowed by law, with the approval of the family court following a positive decision by a multidisciplinary committee. If the family presents a positive de...

Background: A finding of an enlarged clitoris in a female newborn, raises the suspicion of abnormal sexual differentiation and the possibility of female virilization, most commonly due to CAH. This often leads to an extensive medical evaluation which can be painful, expensive, and stressful for the patient and her family. Medical literature does not provide accurate values of a normal clitoris size. According to the few studies available, the current norm rang...

In recent years we have witnessed an increase in the demand for health care by minors with gender diversity. Comprehensive biopsychosocial care for these individuals is a complex process, which must be facilitated for all of them.Objective: The survey strategy aimed at primary care pediatricians aims to provide the starting point for proposals for improvement, in response to the needs expressed by professionals. It is also intended to co...

We present the case of a 15-year-old girl who presented with primary amenorrhoea. On examination she had absent pubertal development (Tanner Stage B1), with a normal-appearing external vagina and vaginal opening. Investigations demonstrated elevated gonadotropins, concerning for primary gonadal failure. Pelvic ultrasound and MRI demonstrated the presence of a rudimentary uterus and the absence of visible gonads. Karyotype confirmed 46 XY. Trio exome sequencing identified a mis...

Introduction: Isolated micropenis is a common presentation to a pediatric endocrine clinic causing significant parental anxiety. Little is known about the dose and duration of treatment as well as long-term outcomes in such children.Aim: To identify the course and predictors of puberty in boys with isolated micropenis.Method: Records of 102 boys presenting with isolated micropenis ...