Previous issue | Volume 98 | ESPE2024

62nd Annual ESPE (ESPE 2024)

Liverpool, UK
16 Nov 2024 - 18 Nov 2024

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The 62nd ESPE Annual Meeting will now be taking place in Liverpool, UK.

Poster Category 1

Thyroid 1

hrp0098p1-97 | Thyroid 1 | ESPE2024

Long term follow up of children with intrathyroidal ectopic thymus

Todisco Tommaso , Pedicelli Stefania , Ubertini Graziamaria , Bizzarri Carla , Grossi Armando , Bottaro Giorgia , Chioma Laura , Fntini Danilo , Loche Sandro , Cappa Marco

Background: Intrathyroidal ectopic thymus (IET) represents a relatively rare embryologic anomaly, often discovered incidentally in paediatric patients. The long-term outcome of IET is not completely clear and differentiation from thyroid nodules is crucial to prevent invasive diagnostic procedures and/or unnecessary surgical interventions. This prospective observational study aims to elucidate the clinical characteristics, diagnostic workup, and long-term outc...

hrp0098p1-98 | Thyroid 1 | ESPE2024

The Influence of multiple gene mutations on the continuation of levothyroxine therapy in patients with congenital hypothyroidism due to dyshormonogenesis

Yoon Jung So , Lee Jeongho

Introduction: Congenital hypothyroidism (CH) is one of the most common endocrine disorder in neonates. A minority arises from dyshormonogenesis, an inborn error of thyroid hormone synthesis. Blood tests commonly reveal elevated thyroid-stimulating hormone levels, decreased thyroxine and thyroglobulin may be low or even undetectable. Thyroid ultrasonography could present a normally sized or enlarged gland. Thyroid scans might demonstrate atypical uptake pattern...

hrp0098p1-99 | Thyroid 1 | ESPE2024

Transient congenital hypothyroidism in a newborn with congenital goiter and compound heterozygosity for thyroglobulin

Nauwynck Elise , Gheldof Alexander , Vanden Eynde Nathalie , Vanbesien Jesse , Depoorter Sylvia , Oosterlynck Caroline , Staels Willem , Gies Inge , De Schepper Jean

Background & aim: Biallelic thyroglobulin (TG) gene variants can cause congenital hypothyroidism (CH), usually presenting with neonatal goiter and permanent in duration. In cases where biallelic truncating TG variants are present, serum TG levels are undetectable, while monoallelic or biallelic missense mutations manifest with circulating TG. Here, we present a case of transient CH resulting from TG deficiency, stemming from compound heterozygosity for a m...

hrp0098p1-100 | Thyroid 1 | ESPE2024

Evaluating Malignancy in Pediatric Thyroid Nodules: The Effectiveness of the Bethesda System and TIRADS

Gazek Natalia , Suarez Mozo Melissa , Celeste Mattone Maria , Santana Olivares Jesus , Ciaccio Marta , Dujovne Noelia

Introduction: The risk of malignancy of pediatric thyroid nodules is determined according to the Bethesda System. Biopsy is performed by fine needle aspiration (FNA) based on ultrasonography (US) patterns. To identify suspicious nodules in adults, the Thyroid Imaging Reporting and Data System (TI-RADS) is widely used; however, its use in pediatrics is less common.Aim: To analyze the usefulness of the Bethesda system and ...

hrp0098p1-101 | Thyroid 1 | ESPE2024

Genetic analyses in a cohort of pediatric patients with congenital hypothyroidism based on congenital hypothyroidism consensus guideline

Kurnaz Erdal , Turkyilmaz Ayberk , Yaralı Oguzhan , Sena Dönmez Ayşe , Çayır Atilla

Background: Pathogenic variants in the genes involved in the formation of thyroid tissue and thyroid hormone secretion have been reported to cause congenital hypothyroidism (CH) in some cases.Aim: This study aimed to evaluate the clinical and genetic findings of CH cases thought to be due to genetic variantsMethod: The study included cases whose genetic analysis was performed in ac...

hrp0098p1-102 | Thyroid 1 | ESPE2024

Diagnosis and treatment of a child affected with a novel thyroid hormone receptor alpha (thra) gene mutation

Felicia Faienza Maria , Giardinelli Silvia , Antonio Moscogiuri Luigi , Urbano Flavia , Matera Emilia , Refetoff Samuel

Case report: We describe a 4-year-old girl, born by vaginal delivery after 41 weeks gestational (length: 55 cm, 99thcentile, weight: 4.8 kg, 99th centile). TSH on newborn screen was normal. Evaluated in the first month of life by gastroenterologists for severe constipation required several hospitalizations and investigation by endoscopy, biopsy, and rectal manometry. Constipation was treated by continuous polyethylene glycol administratio...

hrp0098p1-103 | Thyroid 1 | ESPE2024

The Relationship Between Antiepileptic Drug Use and Central and Peripheral Thyroid Hormone Sensitivity

Ali Oktay Mehmet , Tuğçe Tunca Küçükali Elif , Döğer Esra , Arhan Ebru , Demir Ercan , Orhun Çamurdan Mahmut , Bideci Aysun

Introduction: There is a complex and multifaceted relationship between antiepileptic drugs (AEDs) and the neuroendocrine system. Thyroid hormone (TH) sensitivity reflects thyroid homeostasis more comprehensively than serum hormone levels. It is clear whether TH sensitivity is associated with the use of AEDs. In this study, the evaluation of thyroid hormone sensitivity is aimed in euthyroid cases treated with antiepileptic drug therapy. In this study, the evalu...

hrp0098p1-104 | Thyroid 1 | ESPE2024

Thyroid nodules in children and adolescents: 26 years of experience in a large single academic center

Gest-Laurent Maxime , Nguyen-Quoc Adrien , Lefevre Christine , Gonzalez-Briceno Laura , Thalassinos Caroline , Flechtner Isabelle , Arrom-Branas Maria-Beatriz , Pinto Graziella , Samara-Boustani Dinane , Kariyawasam Dulanjalee , Monpeyssen Hervé , Sarnacki Sabine , Couloigner Vincent , Polak Michel , Stoupa Athanasia

Introduction: Thyroid nodular disease in paediatric age has a lower prevalence but higher rate of malignancy compared to adults. The most frequent risk factors for thyroid cancer are young age, family history, underlying thyroid disease, previous malignancy, genetic predisposition and radiation exposure.Objectives: Describe the demographics, nodules’ etiology and malignancy characteristics and compare the diagnosti...

hrp0098p1-105 | Thyroid 1 | ESPE2024

Presentation and outcome of ATA-Pediatric low-risk differentiated thyroid carcinoma (PLR-DTC) with high-invasive molecular alterations

Papendieck Patricia , Eugenia Masnat Maria , Boycho Marisa , Colli Sandra , Victoria Preciado Maria , Lorenzetti Mario , Arcari Andrea , Chiesa Ana

PLR-DTC patients defined as having a tumor grossly confined to the thyroid with minimal or no central lymph nodes comprises 40% of all pediatric DTC followed-up in our center. High-invasive molecular alterations (HIMA) have been reported recently in around 57% of these patients with a still not clear explanation on their influence in outcome.Objective: To report the characterization of a small group of PLR-DTC patients who were positive ...