Previous issue | Volume 98 | ESPE2024

62nd Annual ESPE (ESPE 2024)

Liverpool, UK
16 Nov 2024 - 18 Nov 2024

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The 62nd ESPE Annual Meeting will now be taking place in Liverpool, UK.

Poster Category 1

Thyroid 3

hrp0098p1-286 | Thyroid 3 | ESPE2024

Has COVID-19 Changed Pediatric Graves' Disease? A Study Investigating Post-Pandemic Trends

Alessandro Naim , Silvia Merlo , Zonca Viviana , Naim Sara , Calevo Mariagrazia , Varotto Carolina , Casalini Emilio , Fava Daniela , Elsa Maria Allegri Anna , Angelelli Alessia , Napoli Flavia , Tedesco Caterina , Di Iorgi Natascia , Gastaldi Roberto , Maghnie Mohamad

Introduction: Graves'disease (GD) is the most common cause of hyperthyroidism in pediatric populations. Recent observations at our tertiary center suggest a potential increase in pediatric GD cases following the COVID-19 pandemic. This single-center study aims to investigate the potential increase in GD cases and explore any significant differences in clinical presentation and outcomes before and after the onset of COVID-19 pandemic.<p class="abstext"...

hrp0098p1-287 | Thyroid 3 | ESPE2024

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hrp0098p1-288 | Thyroid 3 | ESPE2024

Assessment of regulatory B cells in peripheral blood and zinc transporter 8 expression in thyroid tissue in children with autoimmune thyroid diseases

Stożek Karolina , Starosz Aleksandra , Opęchowska Aleksandra , Bossowski Filip , Moniuszko Marcin , Grubczak Kamil , Bossowski Artur

Introduction: There has been a growing trend in the incidence of autoimmune thyroid diseases (ATD) in the pediatric group of patients. The new aspects of its pathogenesis may contribute to understand innovative methods of prevention and treatment. Regulatory B cells (Breg) allow the maintenance of immune homeostasis by neutralizing the negative reactions of effector cells. Attention has been recently paid also to the new environmental factor like zinc and its ...

hrp0098p1-289 | Thyroid 3 | ESPE2024

Papillary thyroid cancer in a teenager with thyroid hormone resistance syndrome: features of postoperative management.

Mikhalina Sofia , Kalinchenko Natalia , Kolodkina Anna

Introduction: In rare cases, patients with thyroid hormone resistance syndrome may develop papillary thyroid cancer. There are only two reported cases of tumor development in children with this condition. Postoperative therapy is a difficult task, due to the persistent increase of thyrotropin (TSH) levels while receiving monotherapy with sodium levothyroxine, and the use of the drug in high doses leads to the development of thyrotoxicosis symptoms. Despite the...

hrp0098p1-290 | Thyroid 3 | ESPE2024

A Retrospective Observational Study of Patients with Differentiated Thyroid Cancer from a Pediatric Endocrinology Clinic in Crete

Smirnaki Pinelopi , Mavraki Lydia , Dimakis Efthimios , Drakonaki Eleni , Koukouraki Sofia , Kapsoritakis Nikolaos , Xekouki Paraskevi

Introduction and Purpose: Differentiated thyroid cancer in children is rare. However, its incidence has increased recently. It differs from adult thyroid cancer in terms of clinical, molecular and pathologic features. Pediatric patients present with advanced disease at the time of diagnosis. They have an excellent prognosis and a 5-year survival rate that reaches 100%. The aim of this study was to record and statistically analyze data from children diagnosed w...

hrp0098p1-291 | Thyroid 3 | ESPE2024

Response to TRIAC therapy in a child with Resistance to Thyroid Hormone beta and behavioural abnormalities

Ramakrishnan Anand , Jarvis Charlotte , Thomas Jay , Armitage Suzanne , Lyons Greta , Halsall David , Chatterjee Krishna , Ramakrishnan Renuka

Introduction: Resistance to thyroid hormone beta, a rare disorder due to mutation in thyroid hormone receptor β, results in raised thyroid hormones with non-suppressed TSH and variable symptoms. Manifestations of RTHb in childhood include failure to thrive, propensity to ENT infections and behavioural abnormalities including ADHD. We report biochemical and behavioural responses to therapy with triiodothyroacetic acid (TRIAC), a centrally-acting thyroid ho...

hrp0098p1-292 | Thyroid 3 | ESPE2024

Congenital autoimmune thyreoiditis with hypothyroidism: first expression of a STAT-3-associated multisystemic disease with further severe autoimmune manifestations

Ververidou Ourania , Lainka Elke , Kampmann Kristina , Steindor Nora , Schäfer Miriam , Manka Eva , Korsch Eckhard , Kiewert Cordula

Introduction: Gain-of-function mutations in the STAT-3-Gene are associated with multisystemic autoimmune disease. The spectrum of disorders described in this context is highly variable and includes lymphoproliferative disease and (poly-) autoimmune endocrinopathies.Case History: A three-year-old boy was admitted with acute liver failure of unknown cause, necessitating a liver transplant. His medical history included cong...

hrp0098p1-293 | Thyroid 3 | ESPE2024

Genetic Etiology in Congenital Hypothyroidism

Gürpınar Gözde , Böke Koçer Gizem , Koçyiğit Esra , Hürmüzlü Közler Selen , Parıltay Erhan , Akın Haluk , Huw Jones Jeremy , Mine Çizmecioğlu Jones Filiz

Introduction: Numerous genetic defects have been identified in relation to congenital hypothyroidism (CH). In recent years, with the increased accessibility of molecular genetic analysis, CH etiology is better understood. We evaluated patients followed with a diagnosis of CH who were diagnosed using next-generation sequencing analysis.Methods: The study included 19 cases (10 females,52.6%). Patients with thyroid gland <e...