ESPE Abstracts

In this study, we investigated pre- and post-operative serum selenium levels in paediatric patients undergoing liver transplantation at a single centre of Kyoto University Hospital. Nineteen children admitted to the Intensive Care Centre of Kyoto University Hospital between 2020 and 2023 were included. Hyposelenaemia was present in 19/19 patients (100%). Up to one and two months postoperatively, 86% and 14% presented with hyposelenaemia, respectively. Hyposelenaemia passed rapidly with intravenous selenium supplementation. The duration of treatment was 36.2 days. Treatment was 2.6 µg/kg/day of selenium. There were no complications of systemic symptoms due to low serum selenium. Comorbidities when hyposelenaemia was diagnosed included hypocarnitineaemia and hypozincaemia, 46% and 62% respectively; secondary hypoparathyroidism with iPTH > 60 was present in 29% of cases. A decrease in selenium after discontinuation of intravenous selenium supplementation was observed in 13% of the patients, but they passed without adverse events with reintroduction of intravenous treatment.