ESPE2024 Poster Category 2 GH and IGFs (22 abstracts)
Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in short stature children born small for gestational age in Korea.
Ha Young Jo 1 , Hyun Ji Jang 2 , Chong Kun Cheon 3 , Ju Young Yoon 3 , Sukdong Yoo 3 , Jung Hyun Lee 4 , Jeong Eun Lee 5 , Ye Jin Kim 6 , Sejin Kim 7 , Hyun-Ji Kim 8 , Im Jeong Choi 9 & Min Jung Kwak 10
1Department of Pediatrics, Pusan National University Hospital, Busan, South Korea. 2Department of Pediatrics, Good Moonhwa Hospital, Busan, South Korea. 3Department of Pediatrics, Pusan National University School of Medicine, Pusan National University Children’s Hospital, Yangsan, South Korea. 4Department of Pediatrics, Kosin University Gospel Hospital, Busan, South Korea. 5Department of Pediatrics, Inje University Busan Paik Hospital, Busan, South Korea. 6Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, South Korea. 7Department of Pediatrics, Dong-A University Hospital, Busan, South Korea. 8Department of Pediatrics, Ilsin Christian Hospital, Busan, South Korea. 9Department of Pediatrics, Mirae Children’s Hospital, Busan, South Korea. 10Department of Pediatrics, Haeundae Bumin Hospital, Busan, South Korea
Background: This study aim ed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria.
Methods: We evaluated 27 children born SGA with short stature and GHD (GHD group) and 23 without GHD (non-GHD group) registered in the LG Growth Study. Growth responses and changes in GH dose over a 2-year GH therapy period were compared, and the factors affecting growth response were investigated.
Results: The standard deviation scores (SDSs) for baseline weight and body mass index (BMI) were significantly lower in boys with GHD than in boys without GHD. The SDS for insulin-like growth factor-1 (IGF-1) was lower among boys with GHD than among boys without GHD, while the SDS for insulin-like growth factor-binding protein-3 (IGFBP-3) was higher among girls with GHD than among girls without GHD; however, there was no significant difference in the comparison between all children with GHD and without. Regardless of the presence of GHD, the difference between chronological age and bone age decreased annually. Notably, there was significantly rapid bone age progression among patients without GHD. The findings showed differences in GH dose according to GHD starting from the 2nd year of therapy, with the non-GHD group receiving a significantly higher dose. Regarding the factors affecting growth response, younger age, bone age, higher height SDS, BMI SDS, and mid-parental height SDS were correlated with increased growth velocity. While change in height SDS and change in growth velocity increased with higher GH dose, the assessment between the GHD and non-GHD groups showed no significant differences.
Conclusion: GHD is rare among children born SGA. Nonetheless, if there are any signs of decreased growth velocity or hypopituitarism, the presence of GHD should be assessed before GH therapy, and personalized therapy based on the results is required.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more