ESPE Abstracts

ESPE Abstracts

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Previous issue | Volume 98 | ESPE2024

62nd Annual ESPE (ESPE 2024)

Liverpool, UK
16 Nov 2024 - 18 Nov 2024

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The 62nd ESPE Annual Meeting will now be taking place in Liverpool, UK.

Poster Category 2

Thyroid

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Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology
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hrp0098p2-271 | Thyroid | ESPE2024

Thyroid Function Changes During Growth Hormone Therapy in Pediatric Patients: A Review and Comparison with Recent Data

Alaaraj Nada , Soliman Ashraf , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Elsayed Nagwa , Sabt Amal

Introduction: Growth hormone therapy is a cornerstone treatment for children with GHD and ISS. Its impact on the hypothalamic-pituitary-thyroid axis, however, has been a subject of ongoing research.Review of Literature:Early Observations (1992-2005): Pirazzoli et al. (1992) and Tang et al. (1997) were among the first to document changes in thyroid function due to ...
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hrp0098p2-272 | Thyroid | ESPE2024

Thyroid function during GH therapy in children with GHD versus those with ISS

Alaaraj Nada , Soliman Ashraf , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Elsayed Nagwa , Bedair Abdelrahman

Introduction: Hypothyroidism in children leads to growth retardation. However, there is some evidence that recombinant human growth hormone (rhGH) therapy could suppress thyroid function. The actual incidence is controversial, however, with some studies showing a rare and others a high occurrence.Aim and Methods: This study examines the effects of Growth Hormone (GH) therapy on thyroid function, specifically focusing on ...
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hrp0098p2-273 | Thyroid | ESPE2024

Post-HSCT Graves’s Disease & Autoimmune Hypothyroidism in Toddlers with Severe Combined Immunodeficiency due to RAG1/RAG2 gene mutation: Keep an eye on the thyroid function following HSCT

Mohamadsalih Ghassan , Chirayath Shiga , Hamdoun Elwaseila , Hussain Khalid

Background: Recombination-activating genes (RAG) 1 and 2 have a key role in adaptive immunity plasticity protecting against enormous diverse antigens [1]. RAG1/RAG2 defects result in several forms of primary immunodeficiencies (PI) which are, nowadays, increasingly treated by Hematopoietic Stem Cell Transplantation (HSCT) [1-3]. Both, PI and HSCT, predispose to autoimmune thyroid disease (AITD) which is otherwise uncommon in young children [4,5]. It is believe...
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hrp0098p2-274 | Thyroid | ESPE2024

Three Cases of Thyroid Hormone Resistance Arising in a Single Family

Jeong Hwalrim , Kwon Eunbyul

Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα - and THRβ -encoded thyroid hormone receptors (THRs). The clinical manifestations range from no symptoms to simple goiter and hypo- or hyperthyroidism, depending on the receptor subtype distribution in the tissues. Here, we report a case of a thyroid hormone-resistance occurring in a 2- year-old boy carrying...
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hrp0098p2-275 | Thyroid | ESPE2024

Persistent tachycardia in a teenager with Graves’ disease on block and replace therapy

Lim Sharon

A 12 year old Caucasian girl presented with a 2-month history of weight loss, anxiety, labile mood and eye discomfort. Initial fT4 was 55.5 pmol/L (NR 6.3 – 14), fT3 > 30 pmol/L (2.5 – 5.7) TSH < 0.005 mU/L (0.3 – 5.6), TSH-receptor and TPO antibodies positive (Table). She was tachycardic (147/min), had a soft non tender goitre and mild lid retraction. She was started on Carbimazole 10 mg TDS (0.7 mg/kg/day) and Propranolol (20 mg TDS) and once the fT4 ...
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hrp0098p2-276 | Thyroid | ESPE2024

Delusional psychosis in a 14-year old female with Graves’ Disease

Okuno Misako , Hotta Aki , Tanaka Yasuhiko , Yokoyama Yoko , Kakuta Tomohiro , Lee Tomoko , Takeshima Yasuhiro

Background: Prominent psychiatric symptoms in hyperthyroidism in children are extremely rare, with the exception of thyroid crisis. Here we report a case with a history of delusional symptoms and impulsive behavior over several years, diagnosed and treated as Graves' disease.Case report: A 14-year-old female patient was admitted to our hospital with cytomegalovirus infection. While in hospital, her mother declared a...
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hrp0098p2-277 | Thyroid | ESPE2024

Atypical Presentation of Childhood Primary Hypothyroidism with Reversible Chronic Kidney Disease stage-2

Mohamadsalih Ghassan , Qutob Dua , Chirayath Shiga , Hamdoun Elwaseila

Introduction: Thyroid hormone (TH) is important for normal growth and function of kidneys [1,2]. Hypothyroidism decreases responsiveness to B-adrenergic stimulation resulting in diminished cardiac contractility, blood pressure, and vasodilator secretion leading to lower renal blood flow [3]. Glomerular filtration rate (GFR) can be reduced by up to 40% and a direct relationship between serum creatinine (SCr) and thyroid-stimulating hormone (TSH) levels was elic...
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hrp0098p2-278 | Thyroid | ESPE2024

Predictive factors of transient congenital hypothyroidism: a retrospective study

Abad Lorna , de Leon Angela , Bon Maceda Ebner

Introduction: The prevalence of transient congenital hypothyroidism (TCH) in the Philippines has not been reported in a large-scale study. The diagnosis of TCH remains difficult due to its numerous possible etiologies. Identifying its predictive factors may aid in earlier diagnosis and decreased risk of overtreatment. This study aim ed to determine the predictive factors for TCH in children with congenital hypothyroidism (CH) detected by newborn screening (NBS...
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hrp0098p2-279 | Thyroid | ESPE2024

Secondary Hypertriglyceridemia Due to Diabetes Mellitus and Hypothyroidism in A Pediatric Patient.

Mammadova Jamala , İsmayılova Senubar , Quliyev Ekber

Up to 20% of children have an underlying potential secondary cause for dyslipidemia. Frequently, the treatment of the underlying cause can lead to normalization of lipid profile.Case report: A 7.5-year-old girl patient presented to us with complaints of short stature, constipation since the age of 3, memory impairment, intolerance to cold, excessive drinking and urination in the last month, and weight loss. On physical examination, her w...
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hrp0098p2-280 | Thyroid | ESPE2024

Neurodevelopmental Outcome in Children with Congenital Hypothyroidism Between 6 to 42 Months of Age – A Cross-Sectional Analytical Study

G Delhikumar C , Mariam Jacob Anju , Mondal Nivedita

Background: Neurological outcomes in congenital hypothyroidism can be optimized by timely diagnosis and treatment. In this study, we compared the neurodevelopmental status of children with congenital hypothyroidism with healthy controls.Methods: This cross-sectional study was performed in southern India between 2022 and 2024 after obtaining ethics approval. The neurodevelopmental outcome of 42 congenital hypothyroidism c...
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hrp0098p2-281 | Thyroid | ESPE2024

Autoimmune Thyroid Disease and Microalbuminuria in Adolescents

Özer Yavuz , Bingöl Aydın Dilek , Evliyaoğlu Olcay

Purpose: The aimof this study is to investigate the presence of microalbuminuria in children and adolescents diagnosed with Graves' Disease (GD) and Hashimoto's thyroiditis (HT) and compare the results with the healthy control group.Materials and Methods: This cross-sectional, single-center study included 35 patients with GH, 29 patients with HT, and 34 healthy control groups. Microalbumin and creatinine measur...
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hrp0098p2-282 | Thyroid | ESPE2024

Thyroid hormone profile and autoimmunity in down syndrome

Günay Aylin , Helvacıoğlu Didem , Yavaş Abalı Zehra , Gürpınar Tosun Büşra , Kahveci Ahmet , Kurt İlknur , Keleştemur Elif , Tuğba Canbaz Aylin , Haliloğlu Belma , Güran Tülay , Bereket Abdullah , Turan Serap

Down syndrome (DS) is the most common chromosomal disorder in live births (1/1500-1/700) and caused by a meiotic nondisjunction (trisomy 21). DS is associated with an increased risk of thyroid disorders in addition to other systemic problems. In this study, we aim ed to investigate the thyroid hormone profiles and associated autoimmune diseases in DS.Material and Method: DS patients, aged 0-18 years, who were followed for thyroid problem...
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hrp0098p2-283 | Thyroid | ESPE2024

Evaluation of thyroid function in a pediatric cohort with chronic spontaneous urticaria: a retrospective, monocenter, observational study

Foti Randazzese Simone , Manti Sara , Salzano Giuseppina , Crescenti Roberta , Scilipoti Mariagrazia , Caminiti Lucia , Crisafulli Giuseppe , Gabriela Wasniewska Malgorzata , Valenzise Mariella

Introduction: Chronic urticaria (CU) affects about 0.3% of pediatric subjects worldwide. Most cases have not identifiable triggers and are classified as chronic spontaneous urticaria (CSU). Etiopathogenesis is complex and the role of thyroid diseases has been widely studied. Indeed, subjects with CSU are held to often have autoimmune disorders, including autoimmune thyroid diseases. This study aims to analyze the possible association of thyroid autoimmunity in...
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hrp0098p2-284 | Thyroid | ESPE2024

Primary congenital hypothyroidism in three sisters: evidence for clinical relevance of two mutations of hitherto unknown significance

Wolf Felicitas , Herbst Susanne , Pohlenz Joachim , Karatsiolis Platonas , Rakicioglu Hande , Kamrath Clemens , A. Wudy Stefan

Introduction: Neonatal screening has undoubtedly proved its worth in detecting cases of congenital hypothyroidism at an early stage. If there are several affected individuals in a family, this should be a reason to consider a hereditary form and to initiate molecular genetic testing.Case descriptions: the firstborn sister (15 yrs) presented with grossly elevated TSH of 223 mU/ml in neonatal screening and with congenital ...
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hrp0098p2-285 | Thyroid | ESPE2024

Levothyroxine poisoning in children is usually benign: A multi-center experience from Turkey

Şen Küçük Kübra , Demir Şule , Deveci Sevim Reyhan , Akgül Fatma , Yalçın Gülşen , Eser Öznur , Bal Alkan , Ergün Elif , Öztürk Sercan , Anık Ahmet

Objective: The objective of this study was to investigate the clinical presentations, laboratory findings, treatment modalities, follow-up strategies employed for children with levothyroxine (LT4) poisoning.Materials-Methods: The study encompassed patients admitted to the respective centers between 2010-2023, who fulfilled the predefined study criteria. Findings were presented as percentages (%), median values with inter...
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hrp0098p2-286 | Thyroid | ESPE2024

Five-Year Experience of Diagnosing and Managing Congenital Hypothyroidism through Dried Blood Spot Newborn Screening in Pakistan: A Comprehensive Clinical Profile and Outcome Analysis

Rehman Bushra , Arif Muzna , Memon Fozia , Majid Hafsa , Kirmani Salman , Nuzhat Humayun Khadija

Background: Congenital Hypothyroidism stands as the most common congenital endocrine disorder in childhood and a leading preventable cause of mental retardation. Despite its prevalence, global newborn detection rates remain suboptimal. The main hurdle in implementing newborn screening in Pakistan is lack of healthcare infrastructure coupled with lack of prevalence data and economic crises. The Aga Khan University Hospital spearheaded congenital hypothyroidism ...
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hrp0098p2-287 | Thyroid | ESPE2024

Abstract withdrawn...
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hrp0098p2-288 | Thyroid | ESPE2024

BRAF mutation in a pediatric patient incidentally discovered with papillary thyroid cancer- case report

Cima Luminita-Nicoleta , Dumitrache Sabina , Grosu Iustina , Oprescu Raluca , Zubaci Ana , Iliescu Marina , Puscasu Diana , Gabriela Barbu Carmen , Fica Simona

Introduction: Papillary thyroid carcinoma (PTC) in the pediatric and young adult population presents contradictory features: it shows higher rates of multifocal disease, local and distant metastasis, and recurrence compared to adults, yet the overall 5-year survival rate remains exceptionally high at 98-100%. In children, RET/PTC rearrangements are the major somatic genetic alterations that drive the formation of PTC. On the other hand, mutations in <...
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hrp0098p2-289 | Thyroid | ESPE2024

What to do for Atypia of Uncertain Significance in Thyroid?

Ozdemir Uslu Zulal , Genel Nebiyye , Tugce Tunca Kucukali Elif , Akin Agah , Cetinkaya Semra , Muratoglu Sahin Nursel

Introduction: Data on atypia of undetermined significance (AUS) in thyroid fine needle aspiration biopsy in children is limited. The American Thyroid Association (ATA) pediatric guideline recommends surgery, while the European Thyroid Association (ETA) recommends fine-needle aspiration biopsy (FNAB) repetition after 6 months. The aimof this study is to determine the markers of malignancy in AUS in children and to discuss the approach to AUS.<p class="abste...
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hrp0098p2-290 | Thyroid | ESPE2024

Graves disease in children and adolescents, results of a multicenter Algerian study

Bensalah Meryem , Boulesnanae Kamelia , Bouferoua Fadila , Bessahraoui Mimouna , Djermane Adel , Kherra Sakina , Selim Nihad , Abes Hakima , Iabbassen Malek , Berkoune Fatma , Taazibt Akli , Chanegriha Mounira , Laadjouz Asmahane , Ouarezki Yasmine

Background: Graves’ disease (GD) is a rare autoimmune affection in children with a female predominance. Its prevalence is about 0,1/100 000py in children and 3/100 000 py in adolescents and characterized by more important frequency of relapse than adults after medical treatment.Aim: Is to evaluate clinical biological radiological and treatment outcome of children and adolescents affected by GD in nine Algerian hosp...
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hrp0098p2-291 | Thyroid | ESPE2024

A case of papillary thyroid cancer in a boy with an aggravated heredity for medullary thyroid cancer

B Bricheva Ella , V Nagaeva Elena , M Abdulkhabirova Fatima , M Lapshina Anastasiya , A Mikheenkov Alexander , N Brovin Dmitry , V Bondarenko Ekaterina

Background: Thyroid cancer (TC) caused by germline mutations most often manifests in childhood. Hereditary forms of TC are divided into two groups: non-medullary and medullary thyroid cancer (MTC). A mutation in RET gene can be detected in about 95% of patients with MTC. If a mutation in RET gene is found, prophylactic thyroidectomy is recommended.Aim: To demonstrate the importance of molecular genetic ...
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hrp0098p2-292 | Thyroid | ESPE2024

Normal Thyroid Gland Size in Healthy Turkish Newborns Living in An Iodine-Sufficient Area: Ultrasonographic Measurements and Comparison of Handheld and Standard Devices

Tuzcu Göksel , Deveci Sevim Reyhan , Gök Mustafa , Anık Ayşe , Anık Ahmet

Objective: The primary aimof this study was to determine the normal values of thyroid gland size measured by ultrasonography (US) in healthy term newborn infants. The secondary objective was to compare the measurements made with handheld and standard US devices.Materials and Methods: Healthy newborn infants aged 0-30 days were included in the study. Thyroid size was measured twice: first between days 1-2 and again betwee...
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hrp0098p2-293 | Thyroid | ESPE2024

Prevalence and Predictor Factors of Transient Congenital Hypothyroidism in Resource-limited Setting

Paulose Abraham , Sreelal Shraddha , KK Diwakar

Background: In recent years, different studies have shown an increasing trend in the prevalence of transient congenital hypothyroidism, varying from 20 to 89%.Aims/Objectives: 1. To determine the prevalence of transient hypothyroidism (TCH) among children diagnosed with congenital hypothyroidism (CH) on newborn screening (NBS). 2. To identify the predictive factors for distinguishing between transient and permanent hypot...
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hrp0098p2-294 | Thyroid | ESPE2024

A Family With Thyroid Hormone Resistance resulting from a rare mutation of thyroid hormone receptor beta gene(THRβ)

Jayasundara Imalka , Atapattu Navoda , Hoole Thabitha , Kumarasiri Ishara , Nimanthi Akila

Thyroid hormone resistance (RTH) is a rare autosomal dominant genetic syndrome with a diminished response to circulating thyroid hormonesin target tissues. It has an incidence of 1:40,000-50,000, and equal sex distribution. Here we report a child with RTH, due to a mutation in THR β gene. 7 years and 5-month-old boy was referred due to thyroid hormone derangement. He was well until 3 years when he developed afebrile seizures and was on Na valproate. He was underg...
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hrp0098p2-295 | Thyroid | ESPE2024

Graves' Disease in Children and Adolescents: A 10 years’ retrospective analysis of patients followed in a Single Center

Gkougkouli Eleni , Dolianiti Maria , Vasilakis Ioannis-Anargyros , Sakka Sofia , Nikolaides Nicolas , Mpinou Maria , Kanaka Gantenbein Christina

Introduction: /Purpose: Graves' disease is the most common cause of hyperthyroidism in children and adolescents. It is an autoimmune disorder characterized by stimulating autoantibodies, leading to increased thyroid hormone release and thyrotoxicosis. Early initiation and long-term treatment, remission, and definitive treatment with thyroidectomy or radioactive iodine present a challenge. This study aims to record the data of patients with Graves' disease foll...
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