ESPE Abstracts

Purpose: The aimof this study is to investigate the presence of microalbuminuria in children and adolescents diagnosed with Graves' Disease (GD) and Hashimoto's thyroiditis (HT) and compare the results with the healthy control group.

Materials and Methods: This cross-sectional, single-center study included 35 patients with GH, 29 patients with HT, and 34 healthy control groups. Microalbumin and creatinine measurements were made in spot urine, and microalbuminuria was evaluated with the microalbumin/creatinine ratio in spot urine.

Results: A total of 98 cases (72 girls, 10 prepubertal) with a median age of 15.0 (12.4–16.2) years were included in the study. Out of the 64 patients with AITD (29 HT and 35 GD) included in the study, 48 (75%) were females and 16 (25%) were males (P < 0.001). No significant difference was observed between the three groups in terms of age, gender, pubertal status, or BMI SDS. The disease duration was 12.0 (6.0–36.0) months in the GH group and 48.0 (27.8–66.3) months in the HT group. Anti-TPO and anti-TG levels were significantly higher in the GH and HT groups compared to the control group (P <0.001, P <0.001, respectively). There was no significant difference between all three groups in terms of eGFR (glomerular filtration rate), spot urine microalbumin levels, and spot urine microalbumin/creatinine ratio (P = 0.160, 0.179, and 0.779, respectively). In the entire cohort, no significant difference was detected between the hyperthyroid and euthyroid groups and the antibody-positive and negative groups in terms of spot urine microalbumin/creatinine ratio (P = 0.383, P = 0.748, respectively). In patients with GH, no significant difference was detected between the hyperthyroid and euthyroid groups in terms of the microalbumin/creatinine ratio in spot urine (P = 0.317). While the microalbumin/creatinine ratio in spot urine was above 30 mg/g in 5 cases (17.2%) with HT, microalbuminuria was detected in 1 case (2.9%) each in the GH group and the control group (P = 0.042). The prevalence of microalbuminuria in children and adolescents with AITD was 9.4%. No correlation was observed between the microalbumin/creatinine ratio in spot urine and the parameters (p > 0.05).

Results: According to the results of this study, no significant difference was found in the microalbumin/creatinine ratio in spot urine in GH and HT cases compared to the control group. However, in cases with HT, the prevalence of microalbuminuria was 17.2%. Based on these results, HT might elevate the likelihood of developing renal dysfunction.