ESPE Abstracts

Introduction: Automated insulin delivery (AID) systems provide an improvement in metabolic control of patients with type 1 diabetes mellitus (DM1). Our center works with 2 systems: (Control-IQ T-slim (A) and Medtronic780G (B)), each one have their own characteristics that could determine the selection of the users. The aimof the study is to evaluate the metabolic control of patients with DM1 after starting AID and evaluate differences between the two treatments.

Methods: Descriptive, retrospective study in a tertiary hospital. Inclusion criteria: children with DM1, more than 2 years of evolution, 1 year of use of AID. Review of medical records and download platforms. Variables collected at baseline, 1, 3 and 12 months: Demographic (age, years of DM1 evolution), clinical (HbA1c, previous insulin therapy), glucometric (% time in range 70-180 mg/dL (TIR), % time in hypoglycemia < 69 mg/dL (TBR), % time in hyperglycemia > 180 mg /dL(TAR), mean glucose(GM) and coefficient of variation(CV)) and insulinometrics (Total daily insulin dose (DTID), %baseline). Statistical study SPSSv23. Significant P < 0.05.

Results: 37 patients. 8 with system A and 29 with B. Patients with system A started AID at a mean age similar to those in group B (10.5 (9-12) vs 12 (6.5-14)) although group B was more heterogeneous with ages between 2 and 16 years. No significant difference in years of disease progression, weight or daily insulin dose. All children in system A were users of multidose insulin (MDI) and flash-type subcutaneous glucose monitoring (CGM), while 58% of those in system B were users of a previous continuous infusion system. At baseline, no differences were found between the two systems. After one month of using the system, differences were observed in TIR and GM, better with system A, these differences were maintained after 3 months. At one year, differences were observed in HbA1, TIR, GM, CV and TAR, better with system A.

Conclusions: Both AID sistems improve metabolic control, it seems that Control-IQ system can achieve it earlier. There are differences between both groups in terms of age and previous experience which suggests a selection bias: more trained patients and more interaction with the sistem in group A. Group B had more heterogeneity and experience in infusers, these could suggest its use for patients who require more automation. -The study has been carried out on a small number of patients so a larger study is required to confirm these results.