ESPE Abstracts

Purpose: Gonadotropin-releasing hormone (GnRH) analog is the first-line treatment with precocious puberty happens before age 8 in girls. This study is aim ed to investigate the relationship between height gain and other factors, specifically to analyze validated tool for predicting adult height for precocious puberty or early puberty.

Method: From January 2022 to June 2022, 32 girls with central precocious puberty who visited the pediatrics outpatient clinics and reached near final adult height were included. Pubertal growth and predicted adult height (PAH) were calculated at diagnosis and for each year following diagnosis using the Bayley-Pinneau method. Predicted adult height was analyzed by BoneXpert version 3.1 (https://bonexpert.com). The patients were divided into two groups: early (before 8 years old) and late (above 8 years old) treated group. Among 33 patients, 30 girls (90%) were treated after 8 years old by GnRH agonist at first diagnosis. The differences in the auxological data, and predicted final adult height were compared using Mann-Whitney U test. The differences in the auxological data were compared using multiple regression analysis.

Results: The mean chronological age was 7.8 ± 0.2 years before 8 years old group vs. 8.6 ± 0.0 years above 8 years old group. The mean PAH at 1st years increased from 157.4 ± 4.2 to 158.9 ± 1.3 cm in early treated group and from 156.9 ± 3.4 to 157.9 ± 3.3 cm in late treated group. After two years of treatment, mean PAH were 161.3 ± 3.9 in early treated group and 159.6 ± 3.0 in late treated group. The pubertal height gains were more achieved in group before 8 years old, which was not statically significant (13.2 ± 1.2 cm vs. 11.9 ± 2.2, respectively). Multifactor logistic regression analysis showed that height gain has significant correlation with height after 1 year treatment and mid-parental height (r²=0.692, P = 0.000). Among 32 patients, 7 patients (21.8%) were achieved more than target height.

Conclusion: The predicted final adult height and growth height gain were higher in early treated group. However, final adult height more than target height were also achieved in late treated group. There is a broad variation in pubertal growth, wherever mid-parental height is one important factor for different growth patterns around puberty in girls.