ESPE Abstracts

Background: Bone and body composition data in Achondroplasia (Ach) treated or not with vosorotide are lacking.Aim: To assess longitudinally body composition and bone markers in children with Ach during Vosorotide treatment (V-Tx).Method: Twenty-one patients (F=11, M=10) underwent DXA evaluation before (T0) and after 12 months of V-Tx (T12): bone mineral density-BMD (g/cm2</sup...

Introduction: Osteoporosis is well described among children with rheumatological conditions. Data on the specific bone deficits and microarchitectural alterations in this group of children are limited. This study aimed to assess the bone microarchitectural alterations in children with rheumatological conditions on long-term glucocorticoids using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods:</stron...

Background: Hypophosphatemic rickets (HR) associated with elevated FGF23 plasma levels is a disorder characterized by renal phosphate wasting, leading to impaired bone mineralization. Conventional therapy, based on oral phosphate and calcitriol, has limited efficacy and tolerability. In 2018, burosumab, a monoclonal antibody against fibroblast growth factor 23 (FGF-23), was approved for the treatment of X-linked hypophosphatemia (XLH). However, data on burosum...

Background: The inactivating mutations of CYP24A1 (OMIM*126065) were first identified in idiopathic infantile hypercalcemia (IH) and named IH-type1 (IH1). However, biallelic mutations were later associated with hypercalcemia at various ages. In our study, we aimed to present the clinical and laboratory findings of our patients who presented with hypercalcemia and were found to have a mutation in CYP24A1.Methods and Resul...

Objective: To investigate the feasibility of constructing a linear regression model to predict the remaining growth potential of adolescent boys based on the radiomics features of knee DR images and clinical characteristics.Methods: Twenty-four adolescent boys with normal growth and whose knee epiphyses had not yet closed were included in the study of anterior posterio DR images of the knee and the height at the time of ...

Purpose: Artificial intelligence (AI) is increasingly used for medical imaging procedures, including automated bone age (BA) evaluation. We aimed to evaluate the agreement between two different BA methods, the IB lab PANDA® and BoneXpert® artificial intelligence methods vs. the manual reference rating in children for BA determination, and to compare the IB lab PANDA performance to the BoneXpert method.<stron...