ESPE Abstracts

Introduction: Hybrid closed loop system (HCLS), also known as automated insulin delivery system, is available in NHS across the four nations of UK. The first commercial HCLS was made available in 2016. Over the last 8 years, successful research on acceptability and efficacy of HCLS has enabled its use widely available. NICE now recommends HCLS in management of children and young people (CYP) with type 1 diabetes (T1D). Paediatric Diabetes Specialist Nurses (PD...

Introduction: Type 1 diabetes mellitus (T1DM) remains the most common form of diabetes in young people. Little is known about the relationship between G6PD deficiency and DM. However, experimental observations support the hypothesis that hyperglycemia can lead to a decrease of G6PD activity, which is of major importance for defense against oxidative stress. Hyperglycemia may lead to the production of free radicals that are known to contribute to the pathogenes...

Research Objectives: Studies have shown that Akkermansiella mucinophila has a positive effect in various metabolic diseases, and can also prevent the onset of spontaneous type 1 diabetic NOD mice. However, its effect on type 1 diabetic mice is not clear. The purpose of this study is to analyze the effect of Akkermansiella mucinophila intervention on type 1 diabetic mice.Research Methods: Thirty male C57BL / 6 mice aged 3...

Background and Objectives: Being born small for gestational age (SGA) as well as growth hormone (GH) treatment are associated with a disturbed glucose-insulin metabolism. We aimed to investigate whether SGA patients have a higher risk of developing an impaired glucose-insulin metabolism under GH treatment in comparison to children with an isolated growth-hormone deficiency (iGHD), to children with obesity and a healthy control group.<str...

Objective: The aim of this study was to evaluate the effectiveness of the Speckle Tracking Carotid Strain (STKS) ultrasonography technique, which allows the measurement of arterial stiffness and strain parameters, in the detection of early atherosclerotic findings in children with type 1 diabetes mellitus (T1DM).Materials and Methods: Children aged 7-18 years with T1DM and no other comorbidities were included in the stud...

Context: Metabolic dysfunction-associated fatty liver disease (MASLD) is the most common chronic liver disease. Recent data showed that MASLD is a common condition also in adults with type 1 diabetes (T1D) and it is independently associated with an increased risk of diabetic complications.Aims: To examine the prevalence of MASLD and its association with glycemic control metrics in children and adolescents with T1D.<p...