ESPE Abstracts

Introduction: The stanniocalcins (STCs) are inhibitory factors of the growth-promoting effects of IGFs through inactivation of pappalysins that favor the release of IGFs from their binding proteins (IGFBPs). STC1 can be involved in the cellular response to stress and plays an important role in cell cycle regulation. Patients with Fanconi Anemia (FA) are more sensitive to oxidative stress that could alter the expression of STC1. Our aim was to assess whether pa...

Background: Dysregulation of metabolic regulatory hormones, particularly reduction of growth hormone (GH) and increase in insulin, often occurs during the progress of obesity. Such GH:insulin balance has recently been proposed critically important in affecting metabolism profiles. Time-restricted feeding (TRF) is an effective strategy against obesity and was tested in this study. Compared to wild type mice, LEAP-2 KO mice is prone to obesity induced by high fa...

Diagnosis of growth hormone (GH) deficiency (GHD) requires direct confirmation by decreased GH peak in stimulation tests (GHST), with measurement of IGF-1 proposed as laboratory screening [Wit et al. 2020]. Taking into account the low incidence of GHD, theoretical incidence of false positive (FP) results of GHST is relatively high [Bright et al. 2022]. Performing two (or more) GHST in each patient decreases the FP rate. Retrospective analysis included data of...

Background: Analysis of insulin-like growth factor-I (IGF-I) is an important tool in the diagnosis of growth hormone deficiency. However, there are significant differences between IGF-I assays and normative data sets, which may have important clinical implications. The aim of this study was to investigate the difference in Z-scores between the iSYS-IDS reference values and the reference values for the IGF-I specific assay used in children.<p class="abstext...

Introduction: Health related Quality of Life (QoL) outcome is used as an argument when continuation or stopping growth hormone (GH) treatment is considered in patients with idiopathic isolated growth hormone deficiency (IIGHD) who tested GH sufficient in mid-puberty (inclusion moment for this study).Aim: To assess potential differences in QoL between patients with IIGHD who discontinued treatment and those who continued ...

To date, knowledge of population dynamics and its repercussions on health required complex, long and expensive field studies. Big data tools are nowadays postulated as a tool of first magnitude for weighted population changes observed in real time if reliable sources of collection and adequate mathematical and computer tools for their assessment are available.Main Objective: Carry out a methodological approach to the use of big data appl...