ESPE2024 Rapid Free Communications Late Breaking (6 abstracts)
Study on effects of poly- and perfluoroalkyl substances on hormones in girls with central precocious puberty
Yan Li 1 , Yanan Xing 2 , Xiaoqin Yin 3 , Jiaoru Yang 1 , Shaolian Zang 1 , Ting Dong 1 , Yitao Pan 2 , Jiayin Dai 2 & Pin Li 1
1Department of Endocrinology, Children’s Hospital of Shanghai, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 2State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China
Background: The pathogenesis of central precocious puberty (CPP) is complex, and exposure to environmental endocrine disruptors leading to CPP deserves attention. Poly- and perfluoroalkyl substances (PFASs) can interfere with sexual development, but there are few reports of their effects on sexual hormones and other hormones in CPP girls.
Objective: To explore the levels of PFASs in CPP girls and healthy control girls aged 7 to 9 years and 11 months, and to clarify the correlation between PFASs and the hypothalamic-pituitary-target gland axis in CPP girls.
Methods: The clinical data and serum samples of 226 CPP girls and 401 normal girls were collected. The differences between the two groups and the correlation between PFASs and hypothalamic-pituitary-target axis hormones were determined by detecting the concentrations of PFASs and hypothalamic-pituitary-target axis hormones.
Results: The exposure concentrations of PFASs were higher among CPP girls, with differences in PFASs being PFBS, PFHxS, and 6:2Cl PFESA, respectively. The differences in PFASs were particularly significant between the ages of 8-9 and 9-10. 2. PFBS was a risk factor for basal LH (OR =1.458， P =0.024), and 6:2Cl-PFESA was a risk factor for basal LH and E2 (OR =1.278， P =0.028； OR =1.249， P =0.047). 3. PFOA and PFBS were significantly negatively correlated with thyroid hormones. 4. There were no significant correlations between PFASs and the hypothalamic-pituitary-adrenal axis and IGF1, IGFBP3 concentrations.
Conclusions: The differences in PFASs between CPP girls and normal girls were confirmed, and the differences in PFASs were identified as PFBS, PFHxS, and 6:2Cl PFESA. 2. PFBS and 6:2Cl PFESA were risk factors for CPP in girls. 3. PFOA and PFBS had inhibitory effects on TSH and T4 synthesis.
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